Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFRWT, EGFRT790M, and EGFRL858R)
Hexahydroquinoline (HHQ) scaffold was constructed and recruited for development of new
series of anticancer agents. Thirty-two new compounds were synthesised where x-ray …
series of anticancer agents. Thirty-two new compounds were synthesised where x-ray …
Exploring the interaction between epidermal growth factor receptor tyrosine kinase and some of the synthesized inhibitors using combination of in-silico and in-vitro …
RR Nasab, M Mansourian… - Research in …, 2018 - journals.lww.com
Quinazoline derivatives are potent inhibitors of human epidermal growth factor receptor
(EGFR) as anticancer agents. In this study, the cytotoxic effects of a new series of …
(EGFR) as anticancer agents. In this study, the cytotoxic effects of a new series of …
Synthesis of Quinoline‐Thiazolidine‐2, 4‐dione Coupled Pyrazoles as in vitro EGFR Targeting Anti‐Breast Cancer Agents and Their in silico Studies
M Bangaru, S Kumar Nukala, PK Kannekanti… - …, 2023 - Wiley Online Library
The synthesis of some new quinoline‐thiazolidine‐2, 4‐dione coupled pyrazoles (7 a–7 n)
via Knoevengal condensation, N‐alkynylation and tandem one‐pot Sonogashira coupling …
via Knoevengal condensation, N‐alkynylation and tandem one‐pot Sonogashira coupling …
Novel morpholin-3-one fused quinazoline derivatives as EGFR tyrosine kinase inhibitors
X Qin, Y Lv, P Liu, Z Li, L Hu, C Zeng, L Yang - Bioorganic & medicinal …, 2016 - Elsevier
A series of novel morpholin-3-one-fused quinazoline derivatives were designed,
synthesized and evaluated as EGFR tyrosine kinase inhibitors. Nineteen compounds …
synthesized and evaluated as EGFR tyrosine kinase inhibitors. Nineteen compounds …
Discovery of new pyrimido [5, 4-c] quinolines as potential antiproliferative agents with multitarget actions: Rapid synthesis, docking, and ADME studies
RA Mekheimer, SMR Allam, MA Al-Sheikh… - Bioorganic …, 2022 - Elsevier
A novel series of pyrimido [5, 4-c] quinoline derivatives variously substituted at positions 2
and 5 have been synthesized, in good to excellent yields, via rapid base-catalyzed …
and 5 have been synthesized, in good to excellent yields, via rapid base-catalyzed …
Design, synthesis, anticancer evaluation, and in silico studies of some thieno[2,3‐d]pyrimidine derivatives as EGFR inhibitors
Abstract New series of 20 thieno [2, 3‐d] pyrimidine derivatives have been synthesized. The
National Cancer Institute evaluated all the newly synthesized compounds for their …
National Cancer Institute evaluated all the newly synthesized compounds for their …
Synthesis, characterization, screening and docking analysis of 4-anilinoquinazoline derivatives as tyrosine kinase inhibitors
We report here the design and synthesis of a series of 4-anilinoquinazoline derivatives, of
which 7 compounds were crystallographically characterized, as epidermal growth factor …
which 7 compounds were crystallographically characterized, as epidermal growth factor …
Structure-based virtual screening, molecular docking, molecular dynamics simulation, and metabolic reactivity studies of quinazoline derivatives for their anti-EGFR …
Background: Epidermal growth factor receptor (EGFR/HER-1) and its role in tumor
development and progression through the mechanism of tumor angiogenesis is prevalent in …
development and progression through the mechanism of tumor angiogenesis is prevalent in …
In silico design, synthesis and activity of potential drug-like chrysin scaffold-derived selective EGFR inhibitors as anticancer agents
S Debnath, M Kanakaraju, M Islam, R Yeeravalli… - … biology and chemistry, 2019 - Elsevier
Background & objective Epidermal growth factor receptor (EGFR) signaling pathway is one
of the promising and well-established targets for anticancer therapy. The objective of the …
of the promising and well-established targets for anticancer therapy. The objective of the …
In vitro cytotoxicity and docking study of novel symmetric and asymmetric dihydropyridines and pyridines as EGFR tyrosine kinase inhibitors
B Mansour, WA Bayoumi, MA El‐Sayed… - Chemical biology & …, 2022 - Wiley Online Library
Quinolines have a weighty effect as anticancer agents and 1, 4‐DHPs have demonstrated
efficacy as anticancer agents in several studies, as well. New hybrid models of symmetric …
efficacy as anticancer agents in several studies, as well. New hybrid models of symmetric …