In silico design, synthesis and activity of potential drug-like chrysin scaffold-derived selective EGFR inhibitors as anticancer agents
S Debnath, M Kanakaraju, M Islam, R Yeeravalli… - … biology and chemistry, 2019 - Elsevier
Background & objective Epidermal growth factor receptor (EGFR) signaling pathway is one
of the promising and well-established targets for anticancer therapy. The objective of the …
of the promising and well-established targets for anticancer therapy. The objective of the …
Discovery of new thieno[2,3-d]pyrimidines as EGFR tyrosine kinase inhibitors for cancer treatment
Background: EGFR has been considered a vital molecular target in cancer management.
Aim: The discovery of new thieno [2, 3-d] pyrimidine derivatives as EGFR tyrosine kinase …
Aim: The discovery of new thieno [2, 3-d] pyrimidine derivatives as EGFR tyrosine kinase …
Novel thioxoimidazolidinone derivatives as dual EGFR and CDK2 inhibitors: Design, synthesis, anticancer evaluation with in silico study
AY Hassan, MA El Deeb, MS El-Zoghbi… - Journal of Molecular …, 2023 - Elsevier
Fifteen thioxoimidazolidinone derivatives were designed as dual EGFR and CDK2 inhibitors
and synthesized following Claisen and Knoevenagel condensation. Derivative 12 showed …
and synthesized following Claisen and Knoevenagel condensation. Derivative 12 showed …
2, 4-Disubstituted quinazolines targeting breast cancer cells via EGFR-PI3K
E Li, Q Lin, Y Meng, L Zhang, P Song, N Li, J Xin… - European journal of …, 2019 - Elsevier
Abstract A series of novel 2, 4-disubstituted quinazolines were synthesized and evaluated
for their anti-tumor activity against five human cancer cells (MDA-MB-231, MCF-7, PC-3 …
for their anti-tumor activity against five human cancer cells (MDA-MB-231, MCF-7, PC-3 …
New substituted quinazoline analogs: Synthesis, anticancer evaluation and docking study
M Naziri, M Mokhtary, F Safa - Journal of Molecular Structure, 2023 - Elsevier
In this work, fifteen new substituted quinazoline analogs were synthesized in good yields
through the reaction of 7-(2-chloroethoxy)-6-methoxy-N-arylquinazoline-4-amine and …
through the reaction of 7-(2-chloroethoxy)-6-methoxy-N-arylquinazoline-4-amine and …
Antitumor activity, multitarget mechanisms, and molecular docking studies of quinazoline derivatives based on a benzenesulfonamide scaffold: Cell cycle analysis
The in vitro cytotoxicity of some substituted quinazolinones, 1–15, was evaluated using NCI
(10 µM) in a full NCI 59–cell line panel assay. Relative to the reference drug, imatinib (PCE …
(10 µM) in a full NCI 59–cell line panel assay. Relative to the reference drug, imatinib (PCE …
Synthesis and in vitro antitumor activities of novel 4-anilinoquinazoline derivatives
V Chandregowda, AK Kush, GC Reddy - European journal of medicinal …, 2009 - Elsevier
A series of 6, 7-dialkoxy-4-anilinoquinazolines were designed, synthesized by substituting
different heterocycles on 6-position and a variety of anilines on 4-position of the quinazoline …
different heterocycles on 6-position and a variety of anilines on 4-position of the quinazoline …
3-Substituted-2, 3-dihydrothiazole as a promising scaffold to design EGFR inhibitors
R El-Haggar, SF Hammad, RI Alsantali, MM Alrooqi… - Bioorganic …, 2022 - Elsevier
The overexpression of EGFR has been recognized as the driver mechanism in the
development of several human malignancies and the clinical use of EGFR inhibitors …
development of several human malignancies and the clinical use of EGFR inhibitors …
Design, synthesis and in vitro anti-proliferative activity of 4, 6-quinazolinediamines as potent EGFR-TK inhibitors
4-Anilino-6-substituted-quinazolines were designed, synthesized and evaluated for EGFR-
TK and tumor growth inhibitory activities. The target compounds were designed with …
TK and tumor growth inhibitory activities. The target compounds were designed with …
Design, synthesis, cytotoxic evaluation and molecular docking of new fluoroquinazolinones as potent anticancer agents with dual EGFR kinase and tubulin …
A series of new fluoroquinazolinone 6–8 and 10a–g derivatives was designed, prepared
and screened for their in vitro cytotoxic activity against human cancer cell lines MCF-7 and …
and screened for their in vitro cytotoxic activity against human cancer cell lines MCF-7 and …