Aquaporin water channels in mammals

K Ishibashi, S Hara, S Kondo - Clinical and experimental nephrology, 2009 - Springer
Abstract Water channels, aquaporins (AQPs), are a family of small integral plasma
membrane proteins that primarily transport water across the plasma membrane. There are …

Physiological importance of aquaporin water channels

AS Verkman - Annals of medicine, 2002 - Taylor & Francis
Aquaporins (AQP) are a family of at least ten homologous water transporting proteins in
mammals that are expressed in many epithelial, endothelial and other tissues. Abnormalities …

Aquaporins: water channel proteins of the cell membrane

K Takata, T Matsuzaki, Y Tajika - Progress in histochemistry and …, 2004 - Elsevier
Aquaporins (AQP) are integral membrane proteins that serve as channels in the transfer of
water, and in some cases, small solutes across the membrane. They are conserved in …

Aquaporin water channels–from atomic structure to clinical medicine

P Agre, LS King, M Yasui, WB Guggino… - The Journal of …, 2002 - Wiley Online Library
The water permeability of biological membranes has been a longstanding problem in
physiology, but the proteins responsible for this remained unknown until discovery of the …

Novel roles of aquaporins revealed by phenotype analysis of knockout mice

AS Verkman - Reviews of physiology biochemistry and pharmacology, 2004 - Springer
The aquaporins (AQPs) are small integral membrane proteins that transport water and in
some cases small solutes such as glycerol. Physiological roles of the ten or more …

Aquaporins in the kidney: from molecules to medicine

S Nielsen, J Frøkiær, D Marples… - Physiological …, 2002 - journals.physiology.org
The discovery of aquaporin-1 (AQP1) answered the long-standing biophysical question of
how water specifically crosses biological membranes. In the kidney, at least seven …

Aquaporins in kidney pathophysiology

Y Noda, E Sohara, E Ohta, S Sasaki - Nature Reviews Nephrology, 2010 - nature.com
Seven aquaporin water channels are expressed in human kidneys, and they have key roles
in maintaining body water homeostasis. Impairment of their function can result in …

Lessons on renal physiology from transgenic mice lacking aquaporin water channels

AS Verkman - Journal of the American Society of Nephrology, 1999 - journals.lww.com
Several aquaporin-type water channels are expressed in kidney: AQP1 in the proximal
tubule, thin descending limb of Henle, and vasa recta; AQP2, AQP3, and AQP4 in the …

The aquaporin family of water channels in kidney

S Nielsen, P Agre - Kidney international, 1995 - Elsevier
The aquaporin family of water channels in kidney. The longstanding puzzle of membrane
water permeability was advanced by the discovery of channel-forming integral protein …

Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels

T Ma, Y Song, B Yang, A Gillespie… - Proceedings of the …, 2000 - National Acad Sciences
Aquaporin-3 (AQP3) is a water channel expressed at the basolateral plasma membrane of
kidney collecting-duct epithelial cells. The mouse AQP3 cDNA was isolated and encodes a …