Our current understanding of the eukaryotic cell cycle attributes a key regulatory role to
cyclin-dependent protein kinases. It is important, therefore, to identify the physiological …

Protein kinases play a central role in the regulation of the eukaryotic cell cycle. Recent
research has concentrated on a particular family of protein kinases, the cyclin-dependent …

Cyclins and cyclin-dependent kinases (Cdks) are universal regulators of cell cycle
progression in eukaryotic cells. Cdk activity is controlled by phosphorylation at three …

INTRODUCTION Cyclins are the activating partners of a highly conserved family of
proteinkinases, the cyclin-dependent kinases (CDKs). A number of diverse cyclins and …

Protein phosphorylation is a key regulatory mechanism for cell cycle control in eukaryotes.
From yeast to humans, cell cycle progression and cell division require the activation of a …

Cyclin‐dependent kinases and their regulatory subunits, the cyclins, are known to regulate
progression through the cell cycle. Yet these same proteins are often expressed in non …

The cell is the basic structural and functional unit of all living organisms, the smallest entity
that exhibits all the characteristics of life. Cells reproduce by means of the cell cycle, the …

Increasing evidence suggests that the eukaryotic cell cycle is controlled at several
checkpoints by different members of a novel class of protein kinase, the cyclin-dependent …

Since their initial discovery in yeast, cyclin-dependent kinases have proven to be universal
regulators of the cell cycle in all eukaryotes. In unicellular eukaryotes, cell cycle progression …

Cyclins regulate the cell cycle by binding to and activating cyclin-dependent kinases (Cdks).
Phosphorylation of specific targets by cyclin–Cdk complexes sets in motion different …