Membrane receptors that are activated by the purine nucleoside adenosine (adenosine
receptors) or by purine or pyrimidine nucleotides (P2Y and P2X receptors) transduce …

The cellular effects of purines and pyrimidines are mediated through an extended
superfamily of purinoceptors, which include metabotropic P1 (adenosine) receptors, and P2 …

Extracellular purines (adenosine, ADP, and ATP) and pyrimidines (UDP and UTP) are
important signaling molecules that mediate diverse biological effects via cellsurface …

Against a background of considerable skepticism and limited efforts in medicinal chemistry,
the pivotal role of adenosine triphosphate (ATP) and related nucleotides as …

Adenosine 5′-triphosphate (ATP), in addition to its intracellular roles, acts as an
extracellular signalling molecule via a rich array of receptors, which have been cloned and …

In the last decade, the field of purinergic pharmacology has continued to grow as the
complexity of the receptor families and the various enzymes involved in purine metabolism …

Research focused on P1 and P2 purinergic receptor function is currently at a critical stage
where considerable efforts in the disciplines of medicinal chemistry, molecular biology, and …

The purine nucleoside adenosine and the purine nucleotide ATP play different roles in the
nervous system. Adenosine acts on a family of G protein coupled receptors, collectively …

The medicinal chemistry and pharmacology of the four subtypes of adenosine receptors
(ARs) and the eight subtypes of P2Y receptors (P2YRs, activated by a range of purine and …

In comparison to other classes of cell surface receptors, the medicinal chemistry at P2X
(ligand-gated ion channels) and P2Y (G protein-coupled) nucleotide receptors has been …