Apolipoprotein (a) kringle-IV type 2 copy number variation is associated with venous thromboembolism

E Sticchi, A Magi, PR Kamstrup, R Marcucci, D Prisco… - PLoS …, 2016 - journals.plos.org
In addition to the established association between high lipoprotein (a)[Lp (a)] concentrations
and coronary artery disease, an association between Lp (a) and venous thromboembolism …

Haplotype of the Lipoprotein (a) Gene Variants rs10455872 and rs3798220 Is Associated with Parameters of Coagulation, Fibrinolysis, and Inflammation in Patients …

S Ugovšek, A Rehberger Likozar, T Levstek… - International Journal of …, 2024 - mdpi.com
Lipoprotein (a)(Lp (a)) is an independent risk factor for future coronary events. Variants
rs10455872 and rs3798220 in the gene encoding Lp (a) are associated with an increased …

Comprehensive Analysis of Genomic Variation in the LPA Locus and Its Relationship to Plasma Lipoprotein(a) in South Asians, Chinese, and European Caucasians

MB Lanktree, SS Anand, S Yusuf… - Circulation …, 2010 - Am Heart Assoc
Background—Functional copy number variation in the apolipoprotein (a) gene (LPA)
underlies a variable number of protein kringle domains repeated in tandem in the lipoprotein …

Effect of two lipoprotein (a)-associated genetic variants on plasminogen levels and fibrinolysis

H Wang, CE Hong, JP Lewis, Y Zhu… - G3: Genes …, 2016 - academic.oup.com
Two genetic variants (rs3798220 and rs10455872) in the apolipoprotein (a) gene (LPA)
have been implicated in cardiovascular disease (CVD), presumably through their …

[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene

S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
Abstract High lipoprotein (a)[Lp (a)] concentrations are one of the most important genetically
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …

Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels

W Lu, YC Cheng, K Chen, H Wang… - Human molecular …, 2015 - academic.oup.com
Abstract Lipoprotein (a)[Lp (a)] is an independent risk factor for atherosclerosis-related
events that is under strong genetic control (heritability= 0.68–0.98). However, causal …

Genetic evidence that lipoprotein (a) associates with atherosclerotic stenosis rather than venous thrombosis

PR Kamstrup, A Tybjærg-Hansen… - … , and vascular biology, 2012 - Am Heart Assoc
Objective—The aim of the present study was to determine whether lipoprotein (a)[Lp (a)],
considered a causal risk factor for cardiovascular disease, primarily promotes thrombosis or …

Lack of association of rs3798220 with small apolipoprotein (a) isoforms and high lipoprotein (a) levels in East and Southeast Asians

M Khalifa, A Noureen, K Ertelthalner, AR Bandegi… - Atherosclerosis, 2015 - Elsevier
Objective The variant allele of rs3798220 in the apolipoprotein (a) gene (LPA) is used to
assess the risk for coronary artery disease (CAD) in Europeans, where it is associated with …

Single nucleotide polymorphisms in exons of the apo (a) kringles IV types 6 to 10 domain affect Lp (a) plasma concentrations and have different patterns in Africans …

M Ogorelkova, HG Kraft, C Ehnholm… - Human molecular …, 2001 - academic.oup.com
Abstract Lipoprotein (a)[Lp (a)] is a complex of apolipoprotein (a)[apo (a)] and low-density
lipoprotein which is associated with atherothrombotic disease. Lp (a) plasma levels are …

The identification and significance of a Thr→ Pro polymorphism in kringle IV type 8 of apolipoprotein (a)

J Prins, FR Lues, YY Van der Hoek… - Thrombosis and …, 1997 - thieme-connect.com
Elevated plasma levels of lipoprotein (a)[Lp (a)] represent a significant independent risk
factor for the development of atherosclerosis. Interindividual levels of apo (a) vary over 1000 …