Currently there are no pharmacokinetic (PK) data to guide antibiotic dosing in critically ill
Australian Indigenous patients with severe sepsis. This study aimed to determine whether …

The pharmacokinetics and pharmacodynamics of meropenem were investigated in 14
critically ill patients with sepsis. Patients with creatinine clearance (CrCl) higher than 50 …

In this study we compared the efficacy of a theoretically optimized two-step infusion therapy
(OTIT; rapid first-step infusion and slow second-step infusion) to the efficacies of prolonged …

BACKGROUND: Pharmacodynamic investigations with antimicrobials define the
relationship between the infecting organism and achievable drug concentrations with …

We performed a prospective, open label, randomized study in intensive care unit patients
with ventilator-associated pneumonia (VAP) to determine the efficacy and safety of empiric …

This prospective, observational multicentre (n= 24) study investigated relationships between
antimicrobial choices and rates of empiric appropriate or adequate therapy, and subsequent …

Objectives: The aim of this study was to compare the pharmacokinetics and
pharmacodynamics of meropenem when administered by 3 h infusion or bolus injection …

Suppression of resistance in a dense Pseudomonas aeruginosa population has previously
been shown with optimized quinolone exposures. However, the relevance to β-lactams is …

Population pharmacokinetic parameters of meropenem in 57 febrile neutropenic patients
and minimal inhibitory concentration (MIC) data for clinically isolated Pseudomonas …

The objective of this study was to describe the pharmacokinetics of meropenem,
administered by continuous infusion (CI) or intermittent bolus (IB), in critically ill patients …