This study investigates the optimal meropenem (MEM) dosing regimen for critically ill
pediatric patients, for which there is a lack of pharmacokinetic (PK) studies. We conducted a …

The aims of this study were to develop a population pharmacokinetic model for meropenem
in Japanese pediatric patients, and to use this model to assess the pharmacodynamics of …

Abstract Objectives In the ASPECT-NP trial, ceftolozane/tazobactam was non-inferior to
meropenem for treating nosocomial pneumonia; efficacy outcomes by causative pathogen …

INTRODUCTION: Carbapenems are broad-spectrum antibiotics that are often employed as
the last line of therapy for patients with nonresponsive nosocomial infections. Consideration …

Nacubactam is a novel, broad-spectrum, β-lactamase inhibitor that is currently under
development as combination therapy with meropenem. This study evaluated the efficacy of …