Activatable superparamagnetic iron oxide nanoparticles scavenge reactive oxygen species in macrophages and endothelial cells

C Nwasike, E Yoo, E Purr, AL Doiron - RSC advances, 2020 - pubs.rsc.org
Reactive oxygen species (ROS) are key markers of inflammation, with varying levels of
superoxide indicating the degree of inflammation. Inflammatory diseases remain the leading …

Incorporation of Targeting Biomolecule Improves Interpolymer Complex-Superparamagnetic Iron Oxide Nanoparticles Attachment to and Activation of T2 MR Signals …

C Nwasike, E Purr, JS Nagi, GJ Mahler… - International Journal of …, 2023 - Taylor & Francis
Introduction Inflammatory diseases are the leading cause of death in the world, accounting
for 3 out of 5 deaths. Despite the abundance of diagnostic tools for detection, most screening …

Decreased reticuloendothelial system clearance and increased blood half-life and immune cell labeling for nano-and micron-sized superparamagnetic iron-oxide …

L Liu, TK Hitchens, Q Ye, Y Wu, B Barbe… - … et Biophysica Acta (BBA …, 2013 - Elsevier
BACKGROUND: Superparamagnetic iron-oxide nanoparticles are useful as contrast agents
for anatomical, functional and cellular MRI, drug delivery agents, and diagnostic biosensors …

New strategies to prolong the in vivo life span of iron-based contrast agents for MRI

A Antonelli, C Sfara, S Battistelli, B Canonico… - PLoS …, 2013 - journals.plos.org
Superparamagnetic iron oxide (SPIO) and ultra small superparamagnetic iron oxide
(USPIO) nanoparticles have been developed as magnetic resonance imaging (MRI) contrast …

Impact of surface coating and particle size on the uptake of small and ultrasmall superparamagnetic iron oxide nanoparticles by macrophages

S Saito, M Tsugeno, D Koto, Y Mori… - International journal …, 2012 - Taylor & Francis
Purpose Magnetic resonance imaging (MRI) using contrast agents like superparamagnetic
iron oxide (SPIO) is an extremely versatile technique to diagnose diseases and to monitor …

Superparamagnetic iron oxide nanoparticles impair endothelial integrity and inhibit nitric oxide production

K Astanina, Y Simon, C Cavelius, S Petry, A Kraegeloh… - Acta Biomaterialia, 2014 - Elsevier
Superparamagnetic iron oxide nanoparticles (SPION) are widely used both clinically and
experimentally for diverse in vivo applications, such as contrast enhancement in magnetic …

Size, charge and concentration dependent uptake of iron oxide particles by non-phagocytic cells

DLJ Thorek, A Tsourkas - Biomaterials, 2008 - Elsevier
A promising new direction for contrast-enhanced magnetic resonance (MR) imaging
involves tracking the migration and biodistribution of superparamagnetic iron oxide (SPIO) …

MRI Contrast-enhancement with superparamagnetic iron oxide nanoparticles amplify macrophage foam cell apoptosis in human and murine atherosclerosis

FME Segers, AV Ruder… - …, 2022 - scholarlypublications …
(Ultra) Small superparamagnetic iron oxide nanoparticles,(U) SPIO, are widely used as
magnetic resonance imaging contrast media and assumed to be safe for clinical …

Magnetic resonance imaging contrast-enhancement with superparamagnetic iron oxide nanoparticles amplifies macrophage foam cell apoptosis in human and …

FME Segers, AV Ruder, MM Westra… - Cardiovascular …, 2022 - academic.oup.com
Abstract Aims (Ultra) Small superparamagnetic iron oxide nanoparticles,(U) SPIO, are
widely used as magnetic resonance imaging contrast media and assumed to be safe for …

Mechanisms for cellular uptake of nanosized clinical MRI contrast agents

EJ Guggenheim, JZ Rappoport, I Lynch - Nanotoxicology, 2020 - Taylor & Francis
Abstract Engineered Nanomaterials (NMs), such as Superparamagnetic Iron Oxide
Nanoparticles (SPIONs), offer significant benefits in a wide range of applications, including …