Skeletal muscle remodelling and contractile dysfunction occur through both acute and
chronic disease processes. These include the accumulation of insoluble aggregates of …

Abstract Background Histone deacetylase 4 (HDAC4) is a stress‐responsive factor that
mediates multiple cellular responses. As a member of class IIa HDACs, HDAC4 shuttles …

Introduction: Histone deacetylase (HDAC) proteins, which counter the activity of histone
acetyltransferases (HATs), are necessary for normal muscle atrophy in response to several …

Huntington's disease (HD) is an incurable and fatal neurodegenerative disorder.
Improvements in the objective measurement of HD will lead to more efficient clinical trials …

ABSTRACT The Forkhead box O (FoxO) transcription factors are activated, and necessary
for the muscle atrophy, in several pathophysiological conditions, including muscle disuse …

Background: In addition to classical neurological symptoms, Huntington's disease (HD) is
complicated by peripheral pathology, including progressive skeletal muscle wasting, and …

Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by the
expansion of a polyglutamine stretch within the huntingtin protein (HTT). The neurological …

Huntington's disease (HD) is a fatal neurodegenerative disorder, caused by a polyglutamine
expansion in the huntingtin protein (HTT). HD has a peripheral component to its pathology …

Duchenne muscular dystrophy (DMD) causes progressive skeletal muscle degeneration
and currently there are few therapeutic options. The identification of new drug targets and …

Background Denervation triggers numerous molecular responses in skeletal muscle,
including the activation of catabolic pathways and oxidative stress, leading to progressive …