Foxp2 Mutations Impair Auditory-Motor Association Learning

S Kurt, SE Fisher, G Ehret - PloS one, 2012 - journals.plos.org
Heterozygous mutations of the human FOXP2 transcription factor gene cause the best-
described examples of monogenic speech and language disorders. Acquisition of proficient …

FOXP2 expression during brain development coincides with adult sites of pathology in a severe speech and language disorder

CSL Lai, D Gerrelli, AP Monaco, SE Fisher, AJ Copp - Brain, 2003 - academic.oup.com
Disruption of FOXP2, a gene encoding a forkhead‐domain transcription factor, causes a
severe developmental disorder of verbal communication, involving profound articulation …

FOXP2 as a molecular window into speech and language

SE Fisher, C Scharff - Trends in Genetics, 2009 - cell.com
Rare mutations of the FOXP2 transcription factor gene cause a monogenic syndrome
characterized by impaired speech development and linguistic deficits. Recent genomic …

High-throughput analysis of promoter occupancy reveals direct neural targets of FOXP2, a gene mutated in speech and language disorders

SC Vernes, E Spiteri, J Nicod, M Groszer… - The American Journal of …, 2007 - cell.com
We previously discovered that mutations of the human FOXP2 gene cause a monogenic
communication disorder, primarily characterized by difficulties in learning to make …

What can mice tell us about Foxp2 function?

CA French, SE Fisher - Current opinion in neurobiology, 2014 - Elsevier
Highlights•Mutations of the FOXP2 gene cause a severe speech and language
disorder.•Mice with Foxp2 disruptions have provided valuable insights into its …

Generation of mice with a conditional Foxp2 null allele

CA French, M Groszer, C Preece, AM Coupe… - genesis, 2007 - Wiley Online Library
Disruptions of the human FOXP2 gene cause problems with articulation of complex speech
sounds, accompanied by impairment in many aspects of language ability. The FOXP2/Foxp2 …

Modified sound-evoked brainstem potentials in Foxp2 mutant mice

S Kurt, M Groszer, SE Fisher, G Ehret - Brain research, 2009 - Elsevier
Heterozygous mutations of the human FOXP2 gene cause a developmental disorder
involving impaired learning and production of fluent spoken language. Previous …

An aetiological Foxp2 mutation causes aberrant striatal activity and alters plasticity during skill learning

CA French, X Jin, TG Campbell, E Gerfen… - Molecular …, 2012 - nature.com
Mutations in the human FOXP2 gene cause impaired speech development and linguistic
deficits, which have been best characterised in a large pedigree called the KE family. The …

FOXP2 and the neuroanatomy of speech and language

F Vargha-Khadem, DG Gadian, A Copp… - Nature Reviews …, 2005 - nature.com
That speech and language are innate capacities of the human brain has long been widely
accepted, but only recently has an entry point into the genetic basis of these remarkable …

The structure of innate vocalizations in Foxp2‐deficient mouse pups

S Gaub, M Groszer, SE Fisher… - Genes, Brain and …, 2010 - Wiley Online Library
Heterozygous mutations of the human FOXP2 gene are implicated in a severe speech and
language disorder. Aetiological mutations of murine Foxp2 yield abnormal synaptic plasticity …