Association of periconception paternal body mass index with persistent changes in DNA methylation of offspring in childhood

N Noor, A Cardenas, SL Rifas-Shiman, H Pan… - JAMA Network …, 2019 - jamanetwork.com
Importance While prenatal nutrition and maternal obesity are recognized as important
contributors to epigenetic changes and childhood obesity, the role of paternal obesity in the …

Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

GC Sharp, R Alfano, A Ghantous… - International Journal …, 2021 - academic.oup.com
Background Accumulating evidence links paternal adiposity in the periconceptional period
to offspring health outcomes. DNA methylation has been proposed as a mediating …

Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium

GC Sharp, LA Salas, C Monnereau… - Human molecular …, 2017 - academic.oup.com
Pre-pregnancy maternal obesity is associated with adverse offspring outcomes at birth and
later in life. Individual studies have shown that epigenetic modifications such as DNA …

Maternal preconception body mass index and offspring cord blood DNA methylation: exploration of early life origins of disease

X Liu, Q Chen, HJ Tsai, G Wang, X Hong… - Environmental and …, 2014 - Wiley Online Library
Maternal obesity is associated with a variety of common diseases in the offspring. One
possible underlying mechanism could be maternal obesity induced alterations in DNA …

DNA methylation profiles in the blood of newborn term infants born to mothers with obesity

A Sasaki, KE Murphy, L Briollais, PO McGowan… - PLoS …, 2022 - journals.plos.org
Maternal obesity is an important risk factor for childhood obesity and influences the
prevalence of metabolic diseases in offspring. As childhood obesity is influenced by …

Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study

CL Martin, D Jima, GC Sharp, LE McCullough… - Epigenetics, 2019 - Taylor & Francis
Pre-pregnancy obesity is an established risk factor for adverse sex-specific cardiometabolic
health in offspring. Epigenetic alterations, such as in DNA methylation (DNAm), are a …

Maternal pre-pregnancy BMI and gestational weight gain, offspring DNA methylation and later offspring adiposity: findings from the Avon Longitudinal Study of Parents …

GC Sharp, DA Lawlor, RC Richmond… - International journal …, 2015 - academic.oup.com
Background: Evidence suggests that in utero exposure to undernutrition and overnutrition
might affect adiposity in later life. Epigenetic modification is suggested as a plausible …

DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

FOL Vehmeijer, LK Küpers, GC Sharp, LA Salas… - Genome medicine, 2020 - Springer
Background DNA methylation has been shown to be associated with adiposity in adulthood.
However, whether similar DNA methylation patterns are associated with childhood and …

Birth weight-for-gestational age is associated with DNA methylation at birth and in childhood

G Agha, H Hajj, SL Rifas-Shiman, AC Just, MF Hivert… - Clinical …, 2016 - Springer
Background Both higher and lower fetal growth are associated with cardio-metabolic health
later in life, suggesting that prenatal developmental programming determines long-term …

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

LK Küpers, C Monnereau, GC Sharp, P Yousefi… - Nature …, 2019 - nature.com
Birthweight is associated with health outcomes across the life course, DNA methylation may
be an underlying mechanism. In this meta-analysis of epigenome-wide association studies …