Gene expression in eukaryotes is subject to extensive regulation at posttranscriptional
levels. One of the most important sites of control involves mRNA 3′ untranslated regions …

The microRNA (miRNA)-mediated repression of protein synthesis in mammalian cells is a
reversible process. Target mRNAs with regulatory AU-rich elements (AREs) in their 3 …

The mammalian RNA-binding protein (RBP) HuR associates with numerous mRNAs
encoding proteins with roles in cell division, cell survival, immune response, and …

The RNA-binding proteins involved in regulation of mRNA post-transcriptional processing
and translation control the fates of thousands of mRNA transcripts and basic cellular …

RNA-binding proteins coordinate the fates of multiple RNAs, but the principles underlying
these global interactions remain poorly understood. We elucidated regulatory mechanisms …

The ubiquitous mRNA-binding protein human antigen R (HuR) and its neuronal relatives
(HuB, HuC, HuD) participate in the post-transcriptional regulation of many AU-rich element …

Gene expression is potently regulated through the action of RNA-binding proteins (RBPs)
and microRNAs (miRNAs). Here, we present evidence of a miRNA regulating an RBP. The …

The 5′ and 3′ untranslated regions (UTRs) of messenger RNAs (mRNAs) function as
platforms that can determine the fate of each mRNA individually and in aggregate. Multiple …

RNA-binding protein HuR modulates the stability and translational efficiency of messenger
RNAs (mRNAs) encoding essential components of the cellular proliferation, growth and …

Translation control of proinflammatory genes has a crucial role in regulating the
inflammatory response and preventing chronic inflammation, including a transition to cancer …