Thrombin-stimulated endothelium synthesizes numerous adhesion molecules to recruit
leukocytes; however, it is unknown which intracellular pathways are responsible for this …

Thrombin, the terminal serine protease in the coagulation cascade, is a proinflammatory
molecule in vivo and induces endothelial activation in vitro. The cellular signaling …

Objective: Thrombin induces leukocyte adherence to endothelial cells via increased
expression of intercellular adhesion molecule-1 (ICAM-1). Although ICAM-1 expression is …

Objective—Proatherosclerotic adhesion of leukocytes to the endothelium is attenuated by
NO. As AMP-activated protein kinase (AMPK) regulates endothelial NO synthesis, we …

The procoagulant thrombin promotes the adhesion of polymorphonuclear leukocytes to
endothelial cells by a mechanism involving expression of intercellular adhesion molecule 1 …

We investigated the mechanisms by which elevated intracellular cAMP concentration
inhibits the thrombin-induced ICAM-1 expression in endothelial cells. Exposure of human …

With the use of a whole blood laminar flow chamber system, we examined the types of
leukocytes, adhesion molecules and the role of nuclear factor-κB (NF-κB) in thrombin …

Activated platelets alter endothelial chemotactic and adhesive properties. Transient
interaction of α-thrombin-activated platelets with endothelial cells is sufficient to induce …

In response to inflammation stimuli, tumor necrosis factor‐α (TNF‐α) induces expression of
cell adhesion molecules (CAMs) in endothelial cells (ECs). Studies have suggested that the …

Inflammation and leukocyte activation/infiltration play a major role in the initiation and
progression of cardiovascular diseases including atherosclerosis and heart failure. Acute …