[HTML][HTML] Ziyuglycoside II alleviates cyclophosphamide-induced leukopenia in mice via regulation of HSPC proliferation and differentiation

H Fang, X Xie, P Liu, Y Rao, Y Cui, S Yang, J Yu… - Biomedicine & …, 2020 - Elsevier
Abstract Ziyuglycoside II (ZGS II) is a major bioactive ingredient of Sanguisorbae officinalis
L., which has been widely used for managing myelosuppression or leukopenia induced by …

[HTML][HTML] Saponins from Sanguisorba officinalis improve hematopoiesis by promoting survival through FAK and Erk1/2 activation and modulating cytokine production in …

X Chen, B Li, Y Gao, J Ji, Z Wu, S Chen - Frontiers in Pharmacology, 2017 - frontiersin.org
Radix Sanguisorbae, the root of Sanguisorba officinalis L. is used as traditional Chinese
medicine. In recent decades, it has been reported to be clinically effective against …

[HTML][HTML] Ziyuglycoside II attenuated OVX mice bone loss via inflammatory responses and regulation of gut microbiota and SCFAs

Y Zhou, Y Zhang, Y Qian, L Tang, T Zhou, Y Xie… - International …, 2024 - Elsevier
Background and purpose Osteoporosis (OP) is a frequent clinical problem for the elderly.
Traditional Chinese Medicine (TCM) has achieved beneficial results in the treatment of OP …

Two birds with one stone: YQSSF regulates both proliferation and apoptosis of bone marrow cells to relieve chemotherapy-induced myelosuppression

M Zeng, Y Zhang, X Zhang, W Zhang, Q Yu… - Journal of …, 2022 - Elsevier
Abstract Ethnopharmacological relevance Yiqi Shengsui formula (YQSSF) is a commonly
used formula to treat chemotherapy-induced myelosuppression, but little is known about its …

Sanguisorba parviflora (Maxim.) Takeda alleviates cyclophosphamide‐induced leukopenia by regulating haematopoietic cell‑specific protein 1‑associated protein X …

L Meng, J Li, X Meng, Y Zhou, J Wang… - Journal of Clinical …, 2021 - Wiley Online Library
What is known and objective We have previously shown that the saponins of Sanguisorba
parviflora (Maxim.) Takeda (Sp. T) relieved cyclophosphamide‐induced myelosuppression …

Ziyuglycoside II inhibits the growth of digestive system cancer cells through multiple mechanisms

Y Zhong, LI Xiao-Yu, Z Fei, CAI Ya-Jie… - Chinese Journal of …, 2021 - Elsevier
Digestive system cancers, including liver, gastric, colon, esophageal and pancreatic
cancers, are the leading cause of cancers with high morbidity and mortality, and the …

Protective effects of peripheral blood of total saponins of Sanguisorba officinalis L. on myelosuppressive mice induced by 60Co-γ ray and its associated mechanism

ZHU Lin-jie, C Lin, H Fei-hong, DAI Yan-ping… - NATURAL PRODUCT …, 2017 - trcw.ac.cn
Protective effects and mechanism of total saponins of Sanguisorba officinalis L.(TSSO) on
myelosuppressivemiceinduced by 60 Co-γ ray was investigated. The myelosuppressivemice …

Ziyuglycoside II exerts antiproliferative and antimetastasis effects on hepatocellular carcinoma cells

W Liao, L Fan, Z Zheng, H Liu, H Deng, M Li… - Anti-Cancer …, 2020 - journals.lww.com
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide.
Phytochemicals are important candidates for developing anticancer agents. Ziyuglycoside II …

Effect and mechanism of specnuezhenide on chemotherapy-induced myelosuppression

J Han, N Sun, J Xing, X Fei, E Cai… - … Chemistry & High …, 2023 - ingentaconnect.com
Objective: This study aimed to investigate the therapeutic effect of Specnuezhenide on
myelosuppression induced by chemotherapy and clarify its mechanism. Methods: In this …

Ziyuglycoside II inhibits the growth of human breast carcinoma MDA-MB-435 cells via cell cycle arrest and induction of apoptosis through the mitochondria dependent …

X Zhu, K Wang, K Zhang, B Huang, J Zhang… - International journal of …, 2013 - mdpi.com
Ziyuglycoside II is one of the major active compounds of Sanguisorba officinalis L., which
has a wide range of clinical applications including hemostasis, antibiosis, anti-inflammation …