[HTML][HTML] Mg2+-and ATP-dependent inhibition of transient receptor potential melastatin 7 by oxidative stress

H Inoue, T Murayama, M Tashiro, T Sakurai… - Free Radical Biology …, 2014 - Elsevier
Transient receptor potential melastatin 7 (TRPM7) is a Ca 2+-and Mg 2+-permeable
nonselective cation channel that contains a unique carboxyl-terminal serine/threonine …

H2O2-stimulated Ca2+ influx via TRPM2 is not the sole determinant of subsequent cell death

JA Wilkinson, JL Scragg, JP Boyle, B Nilius… - Pflügers Archiv-European …, 2008 - Springer
Activation of transient receptor potential melastatin 2 (TRPM2), a non-selective, Ca 2+-
permeable cation channel, is implicated in cell death. Channel opening is stimulated by …

A key role for Mg2+ in TRPM7's control of ROS levels during cell stress

HC Chen, LT Su, O González-Pagán… - Biochemical …, 2012 - portlandpress.com
The TRPM7 (transient receptor potential melastatin 7) channel has been shown to play a
pivotal role in cell survival during brain ischaemia as well as in the survival of other cell …

Characterization and optimization of the novel transient receptor potential melastatin 2 antagonist tatM2NX

I Cruz-Torres, DS Backos, PS Herson - Molecular pharmacology, 2020 - ASPET
Transient receptor potential melastatin 2 (TRPM2) is a calcium-permeable channel activated
by adenosine diphosphate ribose metabolites and oxidative stress. TRPM2 contributes to …

[HTML][HTML] Identification of direct and indirect effectors of the transient receptor potential melastatin 2 (TRPM2) cation channel

B Tóth, L Csanády - Journal of Biological Chemistry, 2010 - ASBMB
Transient receptor potential melastatin 2 (TRPM2) is a Ca 2+-permeable cation channel
involved in physiological and pathophysiological processes linked to oxidative stress …

Development and validation of a cell-based high-throughput screening assay for TRPM2 channel modulators

Y Song, B Buelow, AL Perraud… - Journal of …, 2008 - journals.sagepub.com
TRPM2 is a member of the transient receptor potential melastatin (TRPM)—related ion
channel family. The activation of TRPM2 induced by oxidative/nitrosative stress leads to an …

Melatonin modulates apoptosis and TRPM2 channels in transfected cells activated by oxidative stress

Ö Çelik, M Nazıroğlu - Physiology & behavior, 2012 - Elsevier
Transient receptor potential melastatin-like 2 (TRPM2) is a non-selective Ca2+ permeable
cation channel and is known to be activated by H2O2, one of the most important indicators of …

Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca2+ entry

S Shimizu, R Yonezawa, T Hagiwara, T Yoshida… - European journal of …, 2014 - Elsevier
Transient receptor potential melastatin 2 (TRPM2) is an oxidative stress-sensitive Ca 2+-
permeable channel that controls Ca 2+ signalling. The activation of Janus kinase 2 (Jak2) by …

Role of TRPM7 in cerebral ischaemia and hypoxia

HS Sun - The Journal of physiology, 2017 - Wiley Online Library
Transient receptor potential melastatin 7 (TRPM7) channel, a calcium‐permeable non‐
selective divalent cation channel, is broadly expressed in various cells and tissues …

Intracellular-produced hydroxyl radical mediates H2O2-induced Ca2+ influx and cell death in rat β-cell line RIN-5F

M Ishii, S Shimizu, Y Hara, T Hagiwara, A Miyazaki… - Cell calcium, 2006 - Elsevier
The melastatin-related transient receptor potential channel TRPM2 is a Ca2+-permeable
channel that is activated by H2O2, and the Ca2+ influx through TRPM2 mediates cell death …