Background Cyclo-oxygenase inhibition for the treatment of colorectal neoplasia has been
studied with renewed interest since the discovery of cyclo-oxygenase (Cox) 2 and the …

Inhibitors of the inducible cyclooxygenase (COX‐2) have emerged as a promising new class
of drugs that may be useful for the prevention of colorectal cancer. Experimental evidence to …

Abstract Cyclooxygenase-2 (COX-2) is an inducible enzyme that regulates prostaglandin
synthesis and is overexpressed at sites of inflammation and in several epithelial cancers …

Cyclooxygenase-2 (Cox2) is an inductible isoenzyme of cyclooxygenase undetectable in
normal colonic mucosa and overexpressed in 80% colonic tumor. Several works in vitro and …

Abstract Cyclooxygenase 2 (COX-2), also called prostaglandin endoperoxide synthase 2, is
involved in colorectal tumor development. This review deals with particular questions raised …

Cyclooxygenase-2 (COX-2) is an inducible enzyme which triggers the biosynthesis of
prostaglandins. COX-2 is activated in response to inflammatory stimuli and is one of the …

Cyclooxygenase (COX) enzyme-dependent arachidonic acid metabolites occupy key
positions in important physiologic processes such as immunity, reproduction, and vascular …

COX-2 is an isoenzyme of cyclooxygenase that is increased in response to growth factors,
cytokines, and other mitogenic stimuli. Upregulation of COX-2 gene expression and …

Background Cyclooxygenase (COX) is the rate-limiting enzyme in the synthesis of
prostaglandins. It exists in two isoforms: COX-1 which is constitutively expressed and COX-2 …

Use of nonsteroidal anti‐inflammatory drugs such as aspirin, which are known to inhibit
cyclooxygenase activity, reduces the relative risk of colorectal cancer in humans by 40–50 …