Mice with vestibular deficiency display hyperactivity, disorientation, and signs of anxiety

R Avni, T Elkan, AA Dror, S Shefer, D Eilam… - Behavioural brain …, 2009 - Elsevier
Previous studies revealed that vestibular cues are crucial for exploration in the absence of
visual cues. The working hypothesis of this study was, accordingly, that mice with vestibular …

Progressive vestibular mutation leads to elevated anxiety

S Shefer, CR Gordon, KB Avraham, M Mintz - Brain research, 2010 - Elsevier
Anxiety disorders are among the most common mental disorders, and are comorbid with
balance disorders in a significant proportion of these individuals. Presently, it is unclear …

Balance deficit enhances anxiety and balance training decreases anxiety in vestibular mutant mice

S Shefer, C Gordon, KB Avraham, M Mintz - Behavioural brain research, 2015 - Elsevier
Abstract Treatment of anxiety disorders by either pharmacological or behavioral means is
applied with the intention to directly target the limbic system or high brain centers that down …

Effects of acquired vestibular pathology on the organization of mouse exploratory behavior

MT Banovetz, RI Lake, AA Blackwell… - Experimental Brain …, 2021 - Springer
Rodent open field behavior is highly organized and occurs spontaneously in novel
environments. This organization is disrupted in mice with vestibular pathology, suggesting …

Otolith dysfunction alters exploratory movement in mice

PA Blankenship, LA Cherep, TN Donaldson… - Behavioural brain …, 2017 - Elsevier
The organization of rodent exploratory behavior appears to depend on self-movement cue
processing. As of yet, however, no studies have directly examined the vestibular system's …

New mouse model for inducing and evaluating unilateral vestibular deafferentation syndrome

R Cassel, P Bordiga, D Pericat, C Hautefort… - Journal of Neuroscience …, 2018 - Elsevier
Background Unilateral vestibular deafferentation syndrome (uVDS) holds a particular place
in the vestibular pathology domain. Due to its suddenness, the violence of its symptoms that …

Impaired perception of gravity leads to altered head direction signals: what can we learn from vestibular-deficient mice?

M Beraneck, FM Lambert - Journal of neurophysiology, 2009 - journals.physiology.org
Many mutant mouse strains display pathological behaviors, such as head tilts, head
bobbing, or circling and waltzing, strongly suggesting that their vestibular system is …

Effects of bilateral vestibular deafferentation on anxiety-related behaviours in Wistar rats

Y Zheng, M Goddard, CL Darlington… - Behavioural brain research, 2008 - Elsevier
Despite frequent reports that patients with vestibular dysfunction exhibit an unusually high
incidence of anxiety disorders, few studies have investigated the emotional effects of …

Long‐term deficits on a foraging task after bilateral vestibular deafferentation in rats

Y Zheng, M Goddard, CL Darlington, PF Smith - Hippocampus, 2009 - Wiley Online Library
Animal studies have shown that bilateral vestibular deafferentation (BVD) causes deficits in
spatial memory that may be related to electrophysiological and neurochemical changes in …

The significance of motion sickness in the vestibular system

M Takahashi, M Ogata, M Miura - Journal of Vestibular …, 1997 - content.iospress.com
In order to clarify the significance of motion sickness in the vestibular system, we compared
the findings of experimental motion sickness between different kinds of subjects, some of …