Progesterone Attenuates Allodynia of Inflamed Temporomandibular Joint through Modulating Voltage‐Gated Sodium Channel 1.7 in Trigeminal Ganglion
RY Bi, XY Zhang, P Zhang, Y Ding… - Pain Research and …, 2020 - Wiley Online Library
Background. Women with temporomandibular disorders (TMDs) experience some
amelioration of pain during pregnancy. Progesterone increases dramatically and steadily …
amelioration of pain during pregnancy. Progesterone increases dramatically and steadily …
Estradiol upregulates voltage-gated sodium channel 1.7 in trigeminal ganglion contributing to hyperalgesia of inflamed TMJ
RY Bi, Z Meng, P Zhang, XD Wang, Y Ding, YH Gan - PLoS One, 2017 - journals.plos.org
Background Temporomandibular disorders (TMDs) have the highest prevalence in women
of reproductive age. The role of estrogen in TMDs and especially in TMDs related pain is not …
of reproductive age. The role of estrogen in TMDs and especially in TMDs related pain is not …
A new hypothesis of sex-differences in temporomandibular disorders: estrogen enhances hyperalgesia of inflamed TMJ through modulating voltage-gated sodium …
RY Bi, Y Ding, YH Gan - Medical hypotheses, 2015 - Elsevier
Objective: Temporomandibular disorders (TMD) are an assorted set of clinical conditions
characterized mainly by pain in the temporomandibular joint (TMJ). TMJ inflammation or …
characterized mainly by pain in the temporomandibular joint (TMJ). TMJ inflammation or …
[PDF][PDF] Non-steroidal anti-inflammatory drugs attenuate hyperalgesia and block upregulation of trigeminal ganglionic sodium channel 1.7 after induction of …
BI Rui Yun, Y Ding, YH Gan - Chin J Dent Res, 2016 - cjdrcsa.com
Objective: To investigate the association between the analgesic effect of non-steroidal
antiinflammatory drugs (NSAIDs) and sodium channel 1.7 (Nav1. 7) expression in the …
antiinflammatory drugs (NSAIDs) and sodium channel 1.7 (Nav1. 7) expression in the …
Involvement of trigeminal ganglionic Nav1.7 in hyperalgesia of inflamed temporomandibular joint is dependent on ERK1/2 phosphorylation of glial cells in rats
RY Bi, XX Kou, Z Meng, XD Wang… - European Journal of …, 2013 - Wiley Online Library
Background Inflammation is a major cause of temporomandibular disorder‐related pain. The
N av1. 7 sodium channel has a critical function in pain perceptions. However, whether and …
N av1. 7 sodium channel has a critical function in pain perceptions. However, whether and …
17-β-estradiol enhanced allodynia of inflammatory temporomandibular joint through upregulation of hippocampal TRPV1 in ovariectomized rats
YW Wu, YP Bi, XX Kou, W Xu, LQ Ma… - Journal of …, 2010 - Soc Neuroscience
Temporomandibular disorders (TMDs) predominantly affect reproductive female patients,
with pain the most frequent complaint. Although estrogens are believed to play important …
with pain the most frequent complaint. Although estrogens are believed to play important …
Prostaglandin E2 Upregulated Trigeminal Ganglionic Sodium Channel 1.7 Involving Temporomandibular Joint Inflammatory Pain in Rats
P Zhang, YH Gan - Inflammation, 2017 - Springer
Abstract Prostaglandin E 2 (PGE 2) is a key proinflammatory mediator that contributes to
inflammatory hyperalgesia. Voltage-gated sodium channel 1.7 (Na v 1.7) plays an important …
inflammatory hyperalgesia. Voltage-gated sodium channel 1.7 (Na v 1.7) plays an important …
17β-Estradiol exacerbated experimental occlusal interference-induced chronic masseter hyperalgesia by increasing the neuronal excitability and TRPV1 function of …
Y Liu, XX Xu, Y Cao, SY Mo, SS Bai, YY Fan… - International Journal of …, 2021 - mdpi.com
Pain symptoms in temporomandibular disorders (TMD) predominantly affect reproductive
women, suggesting that estrogen regulates pain perception. However, how estrogen …
women, suggesting that estrogen regulates pain perception. However, how estrogen …
Glial interleukin-1β upregulates neuronal sodium channel 1.7 in trigeminal ganglion contributing to temporomandibular joint inflammatory hypernociception in rats
P Zhang, RY Bi, YH Gan - Journal of neuroinflammation, 2018 - Springer
Background The proinflammatory cytokine interleukin-1β (IL-1β) drives pain by inducing the
expression of inflammatory mediators; however, its ability to regulate sodium channel 1.7 …
expression of inflammatory mediators; however, its ability to regulate sodium channel 1.7 …
Estrogens exacerbate nociceptive pain via up-regulation of TRPV1 and ANO1 in trigeminal primary neurons of female rats
K Yamagata, M Sugimura, M Yoshida, S Sekine… - …, 2016 - academic.oup.com
Several trigeminal pain disorders show sex differences, and high levels of estrogens may
underlie these differences. The interaction between transient receptor potential vanilloid 1 …
underlie these differences. The interaction between transient receptor potential vanilloid 1 …