Humans encode two inflammatory caspases that detect cytoplasmic LPS, caspase‐4 and
caspase‐5. When activated, these trigger pyroptotic cell death and caspase‐1‐dependent IL …

Caspase-11 detection of intracellular lipopolysaccharide (LPS) from invasive Gram-negative
bacteria mediates noncanonical activation of the NLRP3 inflammasome. While avirulent …

The macrophage NLRC4 inflammasome drives potent innate immune responses against
Salmonella by eliciting caspase-1-dependent proinflammatory cytokine production (eg …

Recognition of microbe‐associated molecular patterns or endogenous danger signals by a
subset of cytosolic PRRs results in the assembly of multiprotein signaling complexes, the so …

Inflammasomes are caspase-1–activating multiprotein complexes. The mouse nucleotide-
binding domain and leucine rich repeat pyrin containing 1b (NLRP1b) inflammasome was …

Pathogen recognition by nucleotide-binding oligomerization domain-like receptor (NLR)
results in the formation of a macromolecular protein complex (inflammasome) that drives …

We recently described the induction of noncanonical IL-1β processing via caspase-8
recruited to ripoptosome signaling platforms in myeloid leukocytes. Here, we demonstrate …

Inflammasome activation culminates in activation of caspase‐1, which leads to the
maturation and subsequent release of cytokines of the interleukin 1 (IL‐1) family and results …

Intracellular pathogens and endogenous danger signals in the cytosol engage NOD-like
receptors (NLRs), which assemble inflammasome complexes to activate caspase-1 and …

NLRC4 and NLRP3, of the NOD-like receptor (NLR) family of intracellular proteins, are
expressed in innate immune cells and are thought to nucleate distinct inflammasome …