[HTML][HTML] Lipids and lipoproteins in health and disease: focus on targeting atherosclerosis

CK Lee, CW Liao, SW Meng, WK Wu, JY Chiang… - Biomedicines, 2021 - mdpi.com
Despite advances in pharmacotherapy, intervention devices and techniques, residual
cardiovascular risks still cause a large burden on public health. Whilst most guidelines …

[HTML][HTML] Lipoproteins and lipids in cardiovascular disease: from mechanistic insights to therapeutic targeting

J Soppert, M Lehrke, N Marx, J Jankowski… - Advanced drug delivery …, 2020 - Elsevier
With cardiovascular disease being the leading cause of morbidity and mortality worldwide,
effective and cost-efficient therapies to reduce cardiovascular risk are highly needed. Lipids …

Future lipid-altering therapeutic options targeting residual cardiovascular risk

M Farnier - Current cardiology reports, 2016 - Springer
Low-density lipoproteins (LDL) play a causal role in the development of atherosclerosis, and
reduction of LDL cholesterol with a statin is a cornerstone in prevention of cardiovascular …

[HTML][HTML] Pathophysiology and treatment of atherosclerosis: Current view and future perspective on lipoprotein modification treatment

SC Bergheanu, MC Bodde, JW Jukema - Netherlands Heart Journal, 2017 - Springer
Recent years have brought a significant amount of new results in the field of atherosclerosis.
A better understanding of the role of different lipoprotein particles in the formation of …

The year in cardiovascular medicine 2021: dyslipidaemia

L Tokgozoglu, C Orringer, HN Ginsberg… - European heart …, 2022 - academic.oup.com
The past year was an exciting time for clinical lipidology when we learnt more about existing
therapies as well as therapies targeting novel pathways discovered through genetic studies …

New therapeutic principles in dyslipidaemia: focus on LDL and Lp (a) lowering drugs

GD Norata, CM Ballantyne… - European heart …, 2013 - academic.oup.com
Dyslipidaemias play a key role in determining cardiovascular risk; the discovery of statins
has contributed a very effective approach. However, many patients do not achieve, at the …

[HTML][HTML] The functional role of lipoproteins in atherosclerosis: novel directions for diagnosis and targeting therapy

Y Lu, X Cui, L Zhang, X Wang, Y Xu, Z Qin… - Aging and …, 2022 - ncbi.nlm.nih.gov
Dyslipidemia, characterized by a high level of lipids (cholesterol, triglycerides, or both), can
increase the risk of developing and progressing atherosclerosis. As atherosclerosis …

[HTML][HTML] New therapeutic approaches to the treatment of dyslipidemia 2: LDL-C and Lp (a)

KA Kim, HJ Park - Journal of Lipid and Atherosclerosis, 2023 - ncbi.nlm.nih.gov
Dyslipidemia is an important risk factor for atherosclerotic cardiovascular disease (ASCVD).
There are abundant and unequivocal data to indicate that low-density lipoproteins (LDL) are …

Emerging therapeutic agents to lower lipoprotein (a) levels

B Kolski, S Tsimikas - Current opinion in lipidology, 2012 - journals.lww.com
Lp (a) remains the last major lipoprotein disorder without any specific therapy. With the
strong and accumulating data on its role as a causal risk factor for CVD, a rationale exists to …

Evolving targets for lipid‐modifying therapy

RQ Do, SJ Nicholls, GG Schwartz - EMBO molecular medicine, 2014 - embopress.org
The pathogenesis and progression of atherosclerosis are integrally connected to the
concentration and function of lipoproteins in various classes. This review examines existing …