Direct cell–cell communication is crucial for many processes in biology, particularly
embryogenesis, interactions between hematopoetic cells, and in the nervous system. This …

Catch bonds are characterized by average lifetimes that initially increase with increasing
tensile force. Recently, they have been implicated in T cell activation, where small numbers …

While in many cases the half-life of T cell receptor (TCR) binding to a particular ligand is a
good predictor of activation potential, numerous exceptions suggest that other physical …

T cells circulate in blood and the lymphatic system, continually engaging cells through
transient non‐specific adhesion. In a normally functioning immune system, these …

Triggering of the T-cell receptor (TCR) can produce very different responses, depending on
the nature of the major histocompatibility complex/antigen peptide (MHCp) ligand. The …

T cells orchestrate adaptive, pathogen-specific immune responses. T cells have a surface
receptor (called TCR) whose ligands are complexes (pMHCs) of peptides (derived from …

Although cellular processes depend on protein–protein interactions, our understanding of
molecular recognition between proteins remains far from comprehensive. Protein–protein …

Although conformational changes in TCRs and peptide Ags presented by MHC protein
(pMHC) molecules often occur upon binding, their relationship to intrinsic flexibility and role …

Antigen-dependent activation of T lymphocytes requires T cell receptor (TCR)-mediated
recognition of specific peptides, together with the MHC molecules to which they are bound …

▪ Abstract The first crystal structures of intact T cell receptors (TCRs) bound to class I peptide-
MHC (pMHCs) antigens were determined in 1996. Since then, further structures of class I …