Molecular classification of prostate cancer using curated expression signatures
High Gleason score is currently the best prognostic indicator for poor prognosis in prostate
cancer. However, a significant number of patients with low Gleason scores develop …
cancer. However, a significant number of patients with low Gleason scores develop …
Gene expression profiles in prostate cancer: association with patient subgroups and tumour differentiation
OJ Halvorsen, AM Øyan, TH Bø… - International …, 2005 - spandidos-publications.com
Prostate carcinoma is the most common cancer of western men and is a markedly
heterogeneous disease. The aim of this study was to identify signatures of differentially …
heterogeneous disease. The aim of this study was to identify signatures of differentially …
[HTML][HTML] Expression signatures that correlated with Gleason score and relapse in prostate cancer
M Bibikova, E Chudin, A Arsanjani, L Zhou, EW Garcia… - Genomics, 2007 - Elsevier
Predicting prognosis in prostate carcinoma remains a challenge when using clinical and
pathologic criteria only. We used an array-based DASL® assay to identify molecular …
pathologic criteria only. We used an array-based DASL® assay to identify molecular …
A hierarchical machine learning model to discover gleason grade-specific biomarkers in prostate cancer
O Hamzeh, A Alkhateeb, JZ Zheng, S Kandalam… - Diagnostics, 2019 - mdpi.com
(1) Background: One of the most common cancers that affect North American men and men
worldwide is prostate cancer. The Gleason score is a pathological grading system to …
worldwide is prostate cancer. The Gleason score is a pathological grading system to …
Discovery and validation of a prostate cancer genomic classifier that predicts early metastasis following radical prostatectomy
Purpose Clinicopathologic features and biochemical recurrence are sensitive, but not
specific, predictors of metastatic disease and lethal prostate cancer. We hypothesize that a …
specific, predictors of metastatic disease and lethal prostate cancer. We hypothesize that a …
Gene expression profiling identifies clinically relevant subtypes of prostate cancer
J Lapointe, C Li, JP Higgins… - Proceedings of the …, 2004 - National Acad Sciences
Prostate cancer, a leading cause of cancer death, displays a broad range of clinical
behavior from relatively indolent to aggressive metastatic disease. To explore potential …
behavior from relatively indolent to aggressive metastatic disease. To explore potential …
Optimizing molecular signatures for predicting prostate cancer recurrence
Y Sun, S Goodison - The Prostate, 2009 - Wiley Online Library
BACKGROUND The derivation of molecular signatures indicative of disease status and
predictive of subsequent behavior could facilitate the optimal choice of treatment for prostate …
predictive of subsequent behavior could facilitate the optimal choice of treatment for prostate …
Automated Gleason grading of prostate cancer tissue microarrays via deep learning
The Gleason grading system remains the most powerful prognostic predictor for patients
with prostate cancer since the 1960s. Its application requires highly-trained pathologists, is …
with prostate cancer since the 1960s. Its application requires highly-trained pathologists, is …
Integration of copy number and transcriptomics provides risk stratification in prostate cancer: a discovery and validation cohort study
Background Understanding the heterogeneous genotypes and phenotypes of prostate
cancer is fundamental to improving the way we treat this disease. As yet, there are no …
cancer is fundamental to improving the way we treat this disease. As yet, there are no …
Prognostic utility of a new mRNA expression signature of Gleason score
Purpose: Gleason score strongly predicts prostate cancer mortality; however, scoring varies
among pathologists, and many men are diagnosed with intermediate-risk Gleason score 7 …
among pathologists, and many men are diagnosed with intermediate-risk Gleason score 7 …