Obesity is a major driver of metabolic diseases such as nonalcoholic fatty liver disease,
certain cancers, and insulin resistance. However, there are no effective drugs to treat …

The liver plays a critical role in lipid metabolism. Hepatic dysfunction is not only the direct
cause of fatty liver disease, but the main risk factor for obesity, diabetes, and other metabolic …

Adipose tissue dysfunction, featured by insulin resistance and/or dysregulated adipokine
production, plays a central role not only in disease initiation but also in the progression to …

Simple Summary A large number of studies report that medicinal herbs and many food
ingredients protect against the development of liver disease because they possess …

Animal studies have shown the beneficial effect of betaine supplementation on reducing
body fat, while the data from human studies are controversial and inconsistent. The objective …

Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive fat deposition in the
liver, which is often associated with disrupted iron homeostasis. Betaine has been reported …

Purpose Nonalcoholic fatty liver disease (NAFLD) is currently the leading cause of chronic
liver disease in developing countries. The pathogenesis is complex, and there is currently …

To assess the effects of betaine on hepatic lipid accumulation and investigate the underlying
mechanism, thirty-two male Sprague–Dawley rats weighing 100 (sd 2· 50) g were divided …

Background Betaine serves as a methyl donor in a reaction converting homocysteine to
methionine. It is commonly used for the treatment of hyperhomocysteinemia in humans …

Identifying markers of human insulin resistance may permit development of new approaches
for treatment and prevention of type 2 diabetes. To this end, we analyzed the fasting plasma …