In contrast to physiological pain, pathological pain is not dependent on the presence of
tissue‐damaging stimuli. One type of pathological pain—neuropathic pain—is often a …

Our laboratory has previously shown that glial activation and increased proinflammatory
cytokine expression are observed in the rat spinal cord following peripheral nerve injuries …

While spinal microglia play a role in early stages of neuropathic pain etiology, whether they
are useful targets to reverse chronic pain at late stages remains unknown. Here, we show …

Microglial activation in the spinal cord plays a central role in the development and
maintenance of chronic pain after a peripheral nerve injury (PNI). There has not yet been a …

Peripheral nerve injury commonly leads to neuropathic pain states fostered, in part, by
neuroimmunologic events. We used two models of neuropathic pain (L5 spinal nerve …

Loss of function is usually considered the major consequence of spinal cord injury (SCI).
However, pain severely compromises the quality of life in nearly 70% of SCI patients. The …

Painful peripheral neuropathies produced by nerve trauma are accompanied by substantial
axonal degeneration and by a response in spinal cord microglia that is characterized by …

Increasing evidence suggests that spinal microglia regulate pathological pain in males. In
this study, we investigated the effects of several microglial and astroglial modulators on …

Spinal cord injury (SCI) impairs sensory systems causing chronic allodynia. Mechanisms
underlying neuropathic pain have been more extensively studied following peripheral nerve …

Paclitaxel is a commonly used cancer chemotherapy drug that frequently causes painful
peripheral neuropathies. The mechanisms underlying this dose-limiting side effect are …