Microglia–neuron signalling in the spinal cord is a key mediator of mechanical allodynia
caused by peripheral nerve injury. We recently reported sex differences in microglia in pain …

Neuropathic pain, a maladaptive and chronic condition that can develop after a lesion or
disease affecting the somatosensory system, is characterized by allodynia, hyperalgesia …

In the spinal cord, neuron and glial cells actively interact and contribute to neurofunction.
Surprisingly, both cell types have similar receptors, transporters and ion channels and also …

Responses resulting from injury to the trigeminal nerve exhibit differences compared with
those caused by lesion of other peripheral nerves. With the aim of elucidating the …

Clinical studies indicate that psychosocial stress contributes to adverse chronic pain
outcomes in patients, but it is unclear how this is initiated or amplified by stress. Repeated …

Morphine-3-glucoronide (M3G) is a major morphine metabolite detected in cerebrospinal
fluid of humans receiving systemic morphine. M3G has little-to-no affinity for opioid receptors …

Aim: To investigate the mechanisms underlying the anti-nociceptive effect of minocycline on
bone cancer pain (BCP) in rats. Methods: A rat model of BCP was established by inoculating …

The activation of glial cells in the CNS has been suggested to be involved in abnormal pain
sensation after peripheral nerve injury. Previous studies demonstrated phosphorylation of …

Numerous preclinical studies support the role of spinal neuroimmune activation in the
pathogenesis of chronic pain, and targeting glia (eg, microglia/astrocyte)-or macrophage …

We examined the effect of p38 mitogen‐activated protein kinase (MAPK) inhibitors in models
of nociception and correlated this effect with localization and expression levels of p38 MAPK …