We examined the effect of p38 mitogen‐activated protein kinase (MAPK) inhibitors in models
of nociception and correlated this effect with localization and expression levels of p38 MAPK …

Astrocytes and microglia in the spinal cord have recently been reported to contribute to the
development of peripheral inflammation-induced exaggerated pain states. Both lowering of …

Background: Although paclitaxel is a frontline antineoplastic agent for treatment of solid
tumors, the paclitaxel-evoked pain syndrome is a serious problem for patients. There is …

Background: HIV-associated sensory neuropathy (HIV-SN) is one of the most common forms
of peripheral neuropathy, affecting about 30% of people with acquired immune deficiency …

Opioid-induced glial activation and its proinflammatory consequences have been
associated with both reduced acute opioid analgesia and the enhanced development of …

Painful distal sensory polyneuropathy (DSP) is the most common neurological complication
of HIV1 infection. Although infection with the virus itself is associated with an incidence of …

High mobility group box 1 protein (HMGB1) is increasingly regarded as an important player
in the spinal regulation of chronic pain. Although it has been reported that HMGB1 induces …

Background: Activation of spinal cord glial cells such as microglia and astrocytes has been
shown to regulate chronic opioid-induced antinociceptive tolerance and hyperalgesia, due …

To elucidate the underlying mechanisms involved in AIDS therapy-induced peripheral
neuropathy, we have developed a model of nucleoside analog reverse transcriptase …

Many commonly used chemotherapeutics including oxaliplatin are associated with the
development of a painful chemotherapy-induced peripheral neuropathy (CIPN). This dose …