[HTML][HTML] ShcA promotes chondrocyte hypertrophic commitment and osteoarthritis in mice through RunX2 nuclear translocation and YAP1 inactivation
A Abou-Jaoude, M Courtes, L Badique… - Osteoarthritis and …, 2022 - Elsevier
Objective Chondrocyte hypertrophic differentiation, a key process in endochondral
ossification, is also a feature of osteoarthritis leading to cartilage destruction. Here we …
ossification, is also a feature of osteoarthritis leading to cartilage destruction. Here we …
Targeting Runx2 expression in hypertrophic chondrocytes impairs endochondral ossification during early skeletal development
M Ding, Y Lu, S Abbassi, F Li, X Li… - Journal of cellular …, 2012 - Wiley Online Library
Runx2 is a known master transcription factor for osteoblast differentiation, as well as an
essential regulator for chondrocyte maturation. Recently, more and more data has shown …
essential regulator for chondrocyte maturation. Recently, more and more data has shown …
[HTML][HTML] PKCε is a regulator of hypertrophic differentiation of chondrocytes in osteoarthritis
V Queirolo, D Galli, E Masselli, RM Borzi… - Osteoarthritis and …, 2016 - Elsevier
Objective Osteoarthritis (OA) is a common and highly debilitating degenerative disease
whose complex pathogenesis and the multiplicity of the molecular processes involved …
whose complex pathogenesis and the multiplicity of the molecular processes involved …
[HTML][HTML] Col10a1-Runx2 transgenic mice with delayed chondrocyte maturation are less susceptible to developing osteoarthritis
Y Lu, M Ding, N Li, Q Wang, J Li, X Li, J Gu… - American journal of …, 2014 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is the most common joint disease affecting close to 27 million Americans.
The pathological change of OA joint is characterized by cartilage degradation and …
The pathological change of OA joint is characterized by cartilage degradation and …
[HTML][HTML] YAP maintains cartilage stem/progenitor cell homeostasis in osteoarthritis
L Zhang, X Wang, G Xia, J Huang, Z Wen… - Journal of Orthopaedic …, 2024 - Elsevier
Background The cartilage stem/progenitor cells (CSPC) play a critical role in maintaining
cartilage homeostasis. However, the effects of phenotypic fluctuations of CSPC on cartilage …
cartilage homeostasis. However, the effects of phenotypic fluctuations of CSPC on cartilage …
[HTML][HTML] Endochondral ossification signals in cartilage degradation during osteoarthritis progression in experimental mouse models
H Kawaguchi - Molecules and cells, 2008 - Elsevier
Osteoarthritis (OA), one of the most common skeletal disorders characterized by cartilage
degradation and osteophyte formation in joints, is induced by accumulated mechanical …
degradation and osteophyte formation in joints, is induced by accumulated mechanical …
[HTML][HTML] The regulatory role of signaling crosstalk in hypertrophy of MSCs and human articular chondrocytes
Hypertrophic differentiation of chondrocytes is a main barrier in application of mesenchymal
stem cells (MSCs) for cartilage repair. In addition, hypertrophy occurs occasionally in …
stem cells (MSCs) for cartilage repair. In addition, hypertrophy occurs occasionally in …
RHEB: a potential regulator of chondrocyte phenotype for cartilage tissue regeneration
As articular cartilage has a limited ability to self‐repair, successful cartilage regeneration
requires clinical‐grade chondrocytes with innate characteristics. However, cartilage …
requires clinical‐grade chondrocytes with innate characteristics. However, cartilage …
[HTML][HTML] Runx2 mediated induction of novel targets ST2 and Runx3 leads to cooperative regulation of hypertrophic differentiation in ATDC5 chondrocytes
E Bonyadi Rad, G Musumeci, K Pichler, M Heidary… - Scientific Reports, 2017 - nature.com
Abstract Knowledge concerning expression and function of Suppression of Tumorigenicity 2
(ST2) in chondrocytes is at present, limited. Analysis of murine growth plates and ATDC5 …
(ST2) in chondrocytes is at present, limited. Analysis of murine growth plates and ATDC5 …
[HTML][HTML] Runx1 contributes to articular cartilage maintenance by enhancement of cartilage matrix production and suppression of hypertrophic differentiation
Osteoarthritis (OA) results from an imbalance of the dynamic equilibrium between the
breakdown and repair of joint tissues. Previously, we reported that Runx1 enhanced …
breakdown and repair of joint tissues. Previously, we reported that Runx1 enhanced …