Sepsis is considered as a disease of profoundly and uncontrollably activated innate immune
response against bacterial infection or their products. Thus, regulation of innate immune …

Sepsis is one of the main causes of mortality in hospitalized patients. Despite the recent
technical advances and the development of novel generation of antibiotics, severe sepsis …

Sepsis progresses to multiple organ dysfunction due to the uncontrolled release of
inflammatory mediators, and a growing body of evidence shows that neural signals play a …

Physiologic anti-inflammatory mechanisms are selected by evolution to control the immune
system and to prevent infectious and inflammatory disorders. Central-acting α 2-agonists …

The vagus nerve can sense peripheral inflammation and transmit action potentials from the
periphery to the brainstem. Vagal afferent signaling is integrated in the brainstem, and …

Background: Sepsis is a serious clinical condition characterized by damage to the immune
system as a result of an uncontrolled response to infection. Septic patients show …

Currently the treatment mainstay of sepsis is early and appropriate antibiotic therapy,
accompanied by aggressive fluid administration, the use of vasopressors when needed and …

[Frontiers in Bioscience 10, 2217-2229, September 1, 2005] 2217 SYMPATHETIC
EXCITOTOXICITY IN SEPSIS: PRO-INFLAMMATORY PRIMING O Page 1 [Frontiers in …

Brain signaling is a crucial event for the body to mount an appropriate response to invading
microorganisms. Pro-inflammatory cytokines are released from infected tissues and reach …

On one side, brain dysfunction is a poorly explored complication of sepsis. On the other side,
brain dysfunction may actively contribute to the pathogenesis of sepsis. The current review …