Activation and signaling of the p38 MAP kinase pathway

T Zarubin, J Han - Cell research, 2005 - nature.com
The family members of the mitogen-activated protein (MAP) kinases mediate a wide variety
of cellular behaviors in response to extracellular stimuli. One of the four main sub-groups …

The p38 signal transduction pathway activation and function

K Ono, J Han - Cellular signalling, 2000 - Elsevier
The p38 signalling transduction pathway, a Mitogen-activated protein (MAP) kinase
pathway, plays an essential role in regulating many cellular processes including …

[HTML][HTML] An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling

J Han, J Wu, J Silke - F1000Research, 2020 - ncbi.nlm.nih.gov
The p38 family is a highly evolutionarily conserved group of mitogen-activated protein
kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all …

p38 MAP kinase's emerging role as a tumor suppressor

DV Bulavin, AJ Fornace - Advances in cancer research, 2004 - books.google.com
The p38 proteins are an evolutionally conserved family of mitogen-activated protein kinases
(MAPK). Recent studies have led to progress in our understanding the roles of p38 MAPK in …

[HTML][HTML] Non-classical p38 map kinase functions: cell cycle checkpoints and survival

TM Thornton, M Rincon - International journal of biological …, 2009 - ncbi.nlm.nih.gov
The p38 MAPK kinase pathway is activated in response to a wide range of cellular stress
stimuli and cytokines. Our understanding of the important functions of p38 MAPK in the …

[HTML][HTML] p38 MAP-kinases pathway regulation, function and role in human diseases

A Cuenda, S Rousseau - Biochimica et Biophysica Acta (BBA)-Molecular …, 2007 - Elsevier
Mammalian p38 mitogen-activated protein kinases (MAPKs) are activated by a wide range
of cellular stresses as well as in response to inflammatory cytokines. There are four …

New insights into the p38γ and p38δ MAPK pathways

A Risco, A Cuenda - Journal of signal transduction, 2012 - Wiley Online Library
The mammalian p38 mitogen‐activated protein kinases (MAPKs) family is composed of four
members (p38α, p38β, p38γ, and p38δ), which are very similar in amino acid sequence but …

Cell cycle regulation by p38 MAP kinases

C Ambrosino, AR Nebreda - Biology of the Cell, 2001 - Elsevier
MAP kinases are signaling intermediaries that allow eukaryotic cells to interpret and
respond to many different stimuli. Three major MAP kinase pathways have been identified …

p38MAPK: stress responses from molecular mechanisms to therapeutics

LR Coulthard, DE White, DL Jones… - Trends in molecular …, 2009 - cell.com
The p38 MAPK protein kinases affect a variety of intracellular responses, with well-
recognized roles in inflammation, cell-cycle regulation, cell death, development …

Mechanisms and functions of p38 MAPK signalling

A Cuadrado, AR Nebreda - Biochemical journal, 2010 - portlandpress.com
The p38 MAPK (mitogen-activated protein kinase) signalling pathway allows cells to
interpret a wide range of external signals and respond appropriately by generating a …