Background In mammals, epigenetic information is established and maintained via the
postreplicative methylation of cytosine residues by the DNA methyltransferases Dnmt1 …

The de novo methyltransferase‐like protein, DNMT3L, is required for methylation of
imprinted genes in germ cells. Although enzymatically inactive, human DNMT3L was shown …

In mammalian cells, DNA methylation patterns are precisely maintained after DNA
replication with defined changes occurring during development. The major DNA …

The DNMT3-like protein, DNMT3L, is required for germ line DNA methylation, although it is
inactive as a DNA methyltransferase per se. Previous studies have shown that DNMT3L …

The DNA cytosine methyltransferase 1 (DNMT1) is a ubiquitous nuclear enzyme that
catalyzes the well-established reaction of placing methyl groups on the unmethylated …

DNA methylation is an epigenetic modification of DNA. There are currently three catalytically
active mammalian DNA methyltransferases, DNMT1,-3a, and-3b. DNMT1 has been shown …

DNA methylation plays a central role in the epigenetic regulation of gene expression during
development and disease. Remarkably, the complex and changing patterns of genomic …

Dnmt1, the principal DNA methyltransferase in mammalian cells, is a large and a highly
dynamic enzyme with multiple regulatory features that can control DNA methylation in cells …

CpG methylation is involved in a wide range of biological processes in vertebrates as well
as in plants and fungi. To date, three enzymes, Dnmt1, Dnmt3a, and Dnmt3b, are known to …

DNA methylation serves as the principal form of post-replicative epigenetic modification. It is
intricately involved in gene regulation and silencing in eukaryotic cells, making significant …