[PDF][PDF] Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype

D Baumjohann, S Preite, A Reboldi, F Ronchi… - Immunity, 2013 - cell.com
T follicular helper (Tfh) cells provide help to B cells and are crucial for establishment of
germinal center (GC) reactions, including production of high-affinity antibodies and …

Follicular helper T cells as cognate regulators of B cell immunity

LJ McHeyzer-Williams, N Pelletier, L Mark… - Current opinion in …, 2009 - Elsevier
Follicular helper T (TFH) cells are a class of helper T cells specialized in the cognate control
of antigen-specific B cell immunity. Upon first contact with antigen-primed B cells …

[PDF][PDF] Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling

EK Deenick, A Chan, CS Ma, D Gatto, PL Schwartzberg… - Immunity, 2010 - cell.com
Effective humoral immunity depends on the support of B cell responses by T follicular helper
(Tfh) cells. Although it has been proposed that Tfh cell differentiation requires TB …

[PDF][PDF] T follicular helper cells have distinct modes of migration and molecular signatures in naive and memory immune responses

D Suan, A Nguyen, I Moran, K Bourne, JR Hermes… - Immunity, 2015 - cell.com
B helper follicular T (Tfh) cells are critical for long-term humoral immunity. However, it
remains unclear how these cells are recruited and contribute to secondary immune …

TFH cells in bystander and cognate interactions with B cells

Z Wan, Y Lin, Y Zhao, H Qi - Immunological reviews, 2019 - Wiley Online Library
Follicular T‐helper (TFH) cells play a crucial role in three aspects of the germinal center
(GC) response. They promote GC formation, arbitrate competition among GC B cells to …

B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells

SK Lee, RJ Rigby, D Zotos, LM Tsai… - Journal of Experimental …, 2011 - rupress.org
T follicular helper cells (Tfh cells) localize to follicles where they provide growth and
selection signals to mutated germinal center (GC) B cells, thus promoting their differentiation …

[HTML][HTML] Unexpected help: follicular regulatory T cells in the germinal center

MM Xie, AL Dent - Frontiers in immunology, 2018 - frontiersin.org
Follicular helper T (Tfh) cells are necessary for germinal center (GC) formation and within
the GC, provide key signals to B cells for their differentiation into plasmablasts and plasma …

Interconnected subsets of memory follicular helper T cells have different effector functions

A Asrir, M Aloulou, M Gador, C Pérals… - Nature …, 2017 - nature.com
Follicular helper T cells regulate high-affinity antibody production. Memory follicular helper T
cells can be local in draining lymphoid organs and circulate in the blood, but the underlying …

Affinity of antigen encounter and other early B-cell signals determine B-cell fate

MJ Benson, LD Erickson, MW Gleeson… - Current opinion in …, 2007 - Elsevier
Three possible effector fates await the naïve follicular B cell following antigen stimulation in
thymus-dependent reactions. Short-lived plasma cells produce an initial burst of germline …

T follicular regulatory cells

PT Sage, AH Sharpe - Immunological reviews, 2016 - Wiley Online Library
Pathogen exposure elicits production of high‐affinity antibodies stimulated by T follicular
helper (Tfh) cells in the germinal center reaction. Tfh cells provide both costimulation and …