Highlights•GCs are important sites of B-cell selection for humoral responses.•GCs can
persist for weeks to months after antigen exposure.•How long GCs persist may be influenced …

Follicular helper T (Tfh) cells provide crucial help to germinal center B (GCB) cells for proper
antibody production, and a specialized subset of regulatory T cells, follicular regulatory T …

Protective antibody responses to vaccination or infection depend on affinity maturation, a
process by which high-affinity germinal center (GC) B cells are selected on the basis of their …

Germinal centers (GCs) are specialized microenvironments formed after infection where
activated B cells can mutate their B‐cell receptors to undergo affinity maturation. A stringent …

T follicular helper (TFH) cells are a specialized subset of effector T cells that provide help to
and thereby select high-affinity B cells in germinal centers (GCs). To examine the dynamic …

Germinal center T follicular helper cells (GCTfh) in lymphatic tissue are critical for B cell
differentiation and protective antibody induction, but whether GCTfh establish clonal …

T follicular helper (Tfh) cells are a distinct type of CD4+ T cell specialized in providing help to
B cells during the germinal centre (GC) reaction. As such, they are critical determinants of …

T-follicular helper (Tfh) cells are a specialized subset of T cells that provide help to B cells
and promote the formation of germinal centers (GCs). Tfh cells transmit important signals to …

T follicular helper (TFH) cells play a crucial part in the development of humoral immunity by
controlling the formation of, and the cellular reactions that occur in, germinal centres. Within …

CD4+ T helper (Th) cells play an instrumental role in orchestrating adaptive immune
responses to invading pathogens through their ability to differentiate into specialized effector …