Current trends on cannabidiol delivery systems: where are we and where are we going?

ÍMM Ramalho, DT Pereira, GBL Galvão… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction Cannabidiol (CBD), a phytocannabinoid from Cannabis sativa, has several
therapeutic properties. However, its high lipophilicity, metabolization, and instability impair …

[PDF][PDF] A systematic review of cannabidiol based dosage forms

AJ Sperry, T Youssef, Y Tuong… - Precis …, 2021 - precisionnanomedicine.com
This review article provides a comprehensive overview and analysis of current and
experimental cannabidiol (CBD) delivery methods and examines the pharmacological …

[HTML][HTML] Towards better delivery of cannabidiol (CBD)

SA Millar, RF Maguire, AS Yates, SE O'Sullivan - Pharmaceuticals, 2020 - mdpi.com
Cannabidiol (CBD) has substantial therapeutic potential, but its development as an effective
drug by the pharmaceutical industry is hindered by intrinsic characteristics such as low …

[HTML][HTML] Strategies to improve cannabidiol bioavailability and drug delivery

SE O'Sullivan, SS Jensen, AR Kolli, GN Nikolajsen… - Pharmaceuticals, 2024 - mdpi.com
The poor physicochemical properties of cannabidiol (CBD) hamper its clinical development.
The aim of this review was to examine the literature to identify novel oral products and …

[HTML][HTML] Cannabidiol for the treatment of brain disorders: therapeutic potential and routes of administration

GTY Yau, W Tai, JC Arnold, HK Chan… - Pharmaceutical …, 2023 - Springer
The use of cannabidiol (CBD) for treating brain disorders has gained increasing interest.
While the mechanism of action of CBD in these conditions is still under investigation, CBD …

[HTML][HTML] Promising nanocarriers to enhance solubility and bioavailability of cannabidiol for a plethora of therapeutic opportunities

L Grifoni, G Vanti, R Donato, C Sacco, AR Bilia - Molecules, 2022 - mdpi.com
In recent years, the interest in cannabidiol (CBD) has increased because of the lack of
psychoactive properties. However, CBD has low solubility and bioavailability, variable …

[HTML][HTML] Current challenges and opportunities for improved cannabidiol solubility

KR Hossain, A Alghalayini, SM Valenzuela - International Journal of …, 2023 - mdpi.com
Cannabidiol (CBD), derived from the cannabis plant, has gained significant attention due to
its potential therapeutic benefits. However, one of the challenges associated with CBD …

Current status and prospects for cannabidiol preparations as new therapeutic agents

PS Fasinu, S Phillips, MA ElSohly… - … : The Journal of Human …, 2016 - Wiley Online Library
States and the federal government are under growing pressure to legalize the use of
cannabis products for medical purposes in the United States. Sixteen states have legalized …

[HTML][HTML] Cannabidiol-loaded nanocarriers and their therapeutic applications

E Assadpour, A Rezaei, SS Das, BV Krishna Rao… - Pharmaceuticals, 2023 - mdpi.com
Cannabidiol (CBD), one of the most promising constituents isolated from Cannabis sativa,
exhibits diverse pharmacological actions. However, the applications of CBD are restricted …

Lipid-based formulations to increase cannabidiol bioavailability: In vitro digestion tests, pre-clinical assessment and clinical trial

MAA De Prá, R Vardanega, CG Loss - International Journal of …, 2021 - Elsevier
Herein, medium-chain triglycerides (MCT), glyceryl monolinoleate (GML), and a self-
emulsifying drug delivery system (SEDDS) for cannabidiol (CBD) delivery were compared …