Synapses are specialized structures that mediate rapid and efficient signal transmission
between neurons and are surrounded by glial cells. Astrocytes develop an intimate …

The extracellular matrix (ECM) of the nervous system regulates numerous events during
development, from neurogenesis and gliogenesis to circuitry formation, as well as in …

A structural scaffold embedding brain cells and vasculature is known as extracellular matrix
(ECM). The physical appearance of ECM in the central nervous system (CNS) ranges from a …

Rapidly emerging evidence implicates perineuronal nets (PNNs) and extracellular matrix
(ECM) molecules that compose or interact with PNNs, in the pathophysiology of several …

The concept of the tripartite synapse proposes that in addition to the presynapse and the
postsynaptic membrane closely apposed processes of astrocytes constitute an integral part …

Extracellular matrix (ECM) molecules that are released by neurons and glial cells form
perineuronal nets (PNNs) and modulate many neuronal and glial functions. PNNs, whose …

Perineuronal nets (PNNs) are lattice-like substructures of the neural extracellular matrix that
enwrap particular populations of neurons throughout the central nervous system. Previous …

Microglia shape the synaptic environment in health and disease, but synapses do not exist
in a vacuum. Instead, pre-and postsynaptic terminals are surrounded by extracellular matrix …

The extracellular matrix (ECM) of the brain has important roles in regulating synaptic
function and plasticity. A juvenile ECM supports the wiring of neuronal networks …

The integrity of the central nervous system (CNS) matrix is crucial for its proper function.
Loss of the lattice-like structure compromise synaptic stability and can lead to the disruption …