Reductions in function within the serotonin (5HT) neuronal system have long been proposed
as etiological factors in depression. Selective serotonin reuptake inhibitors (SSRIs) are the …

Selective serotonin reuptake inhibitors (SSRIs) are a major class of antidepressants that act
by blocking inward transport of serotonin (5-HT) into presynaptic neurons mediated by the …

Probably the foremost hypothesis of depression is the 5-hydroxytryptamine (5-HT, serotonin)
deficiency hypothesis. Accordingly, anomalies in putative 5-HT biomarkers have repeatedly …

The neurotransmitter serotonin (5-HT) plays an important role in both the peripheral and
central nervous systems. The biosynthesis of serotonin is regulated by two rate-limiting …

The importance of reversing brain serotonin (5-HT) deficiency and promoting hippocampal
neurogenesis in the mechanisms of action for antidepressants remain highly controversial …

Disorders of emotion regulation such as anxiety disorders and depression are common and
yet debilitating. Accumulating evidence suggests involvement of serotonin (5-HT) in the …

The interaction between genes and environment plays a significant role in the pathogenesis
of major depression and mood disorders. Preclinical and clinical studies have established …

Serotonin is a major neurotransmitter in the central nervous system (CNS). Dysregulation of
serotonin transmission in the CNS is reported to be related to different psychiatric disorders …

Brain serotonin (5-HT) deficiency and exposure to psychosocial stress have both been
implicated in the etiology of depression and anxiety disorders, but whether 5-HT deficiency …

Polymorphisms in the TPH2 gene coding for the serotonin synthesizing enzyme in the brain
are considered as risk factors associated with depression and anxiety in humans. However …