Mutations in the progranulin (GRN) gene have recently been reported as a cause of the
frontotemporal dementia (FTD) syndrome. We performed a clinical, neuropathological and …

Frontotemporal dementia (FTD), characterized by behavioural and language disorders, is a
clinically, genetically and pathologically heterogeneous group of diseases. The most …

In the last decade familial frontotemporal dementia (FFTD) has emerged as a distinct clinical
disease entity characterized by clinical and genetic heterogeneity. Here, we provide an …

Frontotemporal dementia (FTD) is the second most common degenerative dementia after
Alzheimer's disease and its Lewy body variant. Clinical pathology can be subdivided in …

Loss of function progranulin (GRN) mutations are a major autosomal dominant cause of
frontotemporal dementia (FTD). Patients with FTD due to GRN mutations (FTD-GRN) …

Frontotemporal lobar degeneration (FTLD) encompasses a heterogeneous group of clinical
syndromes that include frontotemporal dementia (FTD), frontotemporal dementia with motor …

TAR DNA-binding protein 43 (TDP-43) is a major pathological protein of sporadic and
familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions …

Dementia of motor neuron disease type (DMND) is a variety of frontotemporal dementia
(FTD) which is pathologically defined by characteristic neuronal ubiquitinated, tau-and …

Abstract Ubiquitin‐positive, tau‐negative, frontotemporal dementia (FTD) is caused by null
mutations in progranulin (PGRN; HUGO gene symbol GRN), suggesting a haploinsufficiency …

Objective: Mutations in the progranulin (PGRN) gene were recently described as the cause
of ubiquitin positive frontotemporal dementia (FTD). Clinical and pathological overlap …