Frontotemporal lobar degeneration (FTLD) is a very heterogeneous disorder. It is genetically
linked to three major genes: microtubule-associated protein tau (MAPT), progranulin (GRN) …

Objective To correlate clinical diagnosis and genetic features with different pathological
substrates in patients with frontotemporal lobar degeneration (FTLD) and corticobasal …

Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is characterized by
progressive decline in behavior, executive function, and language. Progranulin (GRN) gene …

Frontotemporal lobar degeneration is a fatal neurodegenerative disease that results in
progressive decline in behavior, executive function and sometimes language. Disease …

Progranulin gene (PGRN) mutations cause frontotemporal lobar degeneration with ubiquitin‐
positive inclusions (FTLD‐U). Patients usually present with a frontotemporal dementia …

In a recent issue of Neuropathology, King and colleagues described a case of a 65-year-old
woman with frontotemporal lobar degeneration (FTLD) with ubiquitinated, tau-negative but …

Reduction of Tau protein expression was described in 2003 by Zhukareva et al. in a variant
of frontotemporal lobar degeneration (FTLD) referred to as diagnosis of dementia lacking …

Loss-of-function mutations in progranulin (GRN) cause ubiquitin-and TAR DNA-binding
protein 43 (TDP-43)-positive frontotemporal dementia (FTLD-U), a progressive …

Importance Mutations in the progranulin (GRN) gene are responsible for 20% of familial
cases of frontotemporal dementias. All cause haploinsufficiency of progranulin, a protein …

Aims To assess the burden of transactive response DNA‐binding protein of 43 kDa (TDP‐
43) inclusions in a unique cohort of old‐age patients with genetic frontotemporal lobar …