BACKGROUND: IL-31 is a newly discovered T-cell cytokine that, when overexpressed in
mice, results in pruritus and skin dermatitis resembling human atopic dermatitis (AD) …

BACKGROUND: IL-31 is produced by activated T lymphocytes, preferentially by TH2 cells.
Transgenic mice overexpressing IL-31 have a phenotype resembling allergic dermatitis in …

BACKGROUND: IL-31 is a novel T-cell–derived cytokine that induces severe pruritus and
dermatitis in transgenic mice, and signals through a heterodimeric receptor composed of IL …

Interleukin-31 (IL-31) is a recently discovered cytokine expressed in many human tissues,
and predominantly by activated CD4+ T cells. IL-31 signals through a heterodimeric receptor …

Background To understand the clinical segments of IL-31 signaling blockade therapy in
pruritus of atopic dermatitis (AD), direct detection of the target proteins in the diseased …

Background Severe pruritus is the primary symptom in atopic dermatitis (AD). Recently, the
novel cytokine IL-31 has been implicated in the itching associated with AD. Objective We …

Abstract Interleukin-31 (IL-31) is a newly discovered cytokine associated with chronic skin
inflammation and pruritus. Patients with atopic dermatitis, chronic spontaneous urticaria …

Background IL-31 is a type 2 cytokine involved in the itch sensation in atopic dermatitis (AD).
The cellular origins of IL-31 are generally considered to be TH 2 cells. Macrophages have …

BACKGROUND: Atopic dermatitis (AD) is an inflammatory skin disease affecting 10% to
20% of children and 1% to 3% of adults in industrialized countries. Enhanced expression of …

Cutaneous T-cell lymphomas (CTCL) are a heterogenous group of non-Hodgkin's
lymphomas of skin-trafficking T lymphocytes (Diamandidou et al., 1996). CTCL patients often …