In vivo investigation on the chronic hepatotoxicity induced by intraperitoneal administration of 10-nm silicon dioxide nanoparticles

M Almansour, S Alarifi, B Jarrar - International journal of …, 2018 - Taylor & Francis
Background Silicon dioxide (silica) nanoparticles (SDNPs) are widely used in
nanotechnology and medicine, but these nanomaterials may carry a high risk for human …

In vivo toxicity of orally administrated silicon dioxide nanoparticles in healthy adult mice

R Hassankhani, M Esmaeillou, AA Tehrani… - … Science and Pollution …, 2015 - Springer
The increasing use of silica nanoparticles (SiNPs) in various applications including
industrial, agriculture, and medicine has raised concerns about their potential risks to human …

Silica nanoparticles induce liver fibrosis via TGF-β1/Smad3 pathway in ICR mice

Y Yu, J Duan, Y Li, Y Li, L Jing, M Yang… - International journal …, 2017 - Taylor & Francis
The liver is one of the target organs of silica nanoparticles (SiO2 NPs) but the toxic
mechanism on the liver still remains unclear. This study aimed to explore the hepatic toxicity …

[PDF][PDF] Effects of different sizes silica nanoparticle on the liver, kidney and brain in rats: Biochemical and histopathological evaluation

Ü Çömelekoğlu, E BALLI, S YALIN, P EROĞLU… - J. Res …, 2019 - apbs.mersin.edu.tr
Silica is among the most popular nanoparticles. Large-scale production and use have
increased the risk of human exposure to silica nanoparticles (SiO2NPs). This study aimed to …

Silica nanoparticles induce hepatotoxicity by triggering oxidative damage, apoptosis, and Bax-Bcl2 signaling pathway

B Aouey, K Boukholda, B Gargouri, HS Bhatia… - Biological trace element …, 2022 - Springer
The increase in the usage of silica nanoparticles (SiNPs) in the industrial and medical fields
has raised concerns about their possible adverse effects on human health. The present …

Pathological mechanisms of liver injury caused by continuous intraperitoneal injection of silica nanoparticles

T Liu, L Li, C Fu, H Liu, D Chen, F Tang - Biomaterials, 2012 - Elsevier
Crystalline silica is well known to induce chronic lung inflammation by inhalation that can
progress to silicosis. Recently, we reported that silica nanoparticles (SN) cause more …

[HTML][HTML] Mechanism of cell death induced by silica nanoparticles in hepatocyte cells is by apoptosis

Y Yang, X Du, Q Wang, J Liu… - International …, 2019 - spandidos-publications.com
Silicon is one of the most widely used chemical materials, and the increasing use of silica
nanoparticles (SNs) highlights the requirement for safety and biological toxicity studies. The …

Silica nanoparticles as hepatotoxicants

H Nishimori, M Kondoh, K Isoda, S Tsunoda… - European Journal of …, 2009 - Elsevier
Nano-size materials are increasingly used in cosmetics, diagnosis, imaging and drug
delivery, but the toxicity of the nano-size materials has never been fully investigated. Here …

In vivo toxicologic study of larger silica nanoparticles in mice

WT Chan, CC Liu, JS Chiang Chiau… - International journal …, 2017 - Taylor & Francis
Silica nanoparticles (SiNPs) are being studied and used for medical purposes. As
nanotechnology grows rapidly, its biosafety and toxicity have frequently raised concerns …

[HTML][HTML] Metabolomic characteristics of hepatotoxicity in rats induced by silica nanoparticles

M Sun, J Zhang, S Liang, Z Du, J Liu, Z Sun… - … and Environmental Safety, 2021 - Elsevier
Silica nanoparticles (SiNPs) have become one of the most widely studied nanoparticles in
nanotechnology for environmental health and safety. Although many studies have devoted …