[HTML][HTML] Altered placental chorionic arterial biomechanical properties during intrauterine growth restriction

SN Saw, JJH Tay, YW Poh, L Yang, WC Tan, LK Tan… - Scientific reports, 2018 - nature.com
Intrauterine growth restriction (IUGR) is a pregnancy complication due to placental
dysfunction that prevents the fetus from obtaining enough oxygen and nutrients, leading to …

Characterization of the hemodynamic wall shear stresses in human umbilical vessels from normal and intrauterine growth restricted pregnancies

SN Saw, YW Poh, D Chia, A Biswas… - … and modeling in …, 2018 - Springer
Significant reductions in blood flow and umbilical diameters were reported in pregnancies
affected by intrauterine growth restriction (IUGR) from placental insufficiency. However, it is …

Mechanical testing and non-linear viscoelastic modelling of the human placenta in normal and growth restricted pregnancies

JS Lau, SN Saw, ML Buist, A Biswas, CNZ Mattar… - Journal of …, 2016 - Elsevier
Abstract Background Intrauterine Growth Restriction (IUGR) is a disease where the placenta
is unable to transfer enough nutrients to the fetus, limiting its growth, and resulting in high …

Hyperelastic Mechanical Properties of Ex Vivo Normal and Intrauterine Growth Restricted Placenta

SN Saw, JYR Low, MHH Ong, YW Poh… - Annals of Biomedical …, 2018 - Springer
Abstract Intrauterine Growth Restriction (IUGR) is a serious and prevalent pregnancy
complication that is due to placental insufficiency and IUGR babies suffer significantly higher …

[HTML][HTML] Increased arterial stiffness and extracellular matrix reorganization in intrauterine growth–restricted fetal sheep

RB Dodson, PJ Rozance, BS Fleenor, CC Petrash… - Pediatric …, 2013 - nature.com
Background: Fetal intrauterine growth restriction (IUGR) results in increased placental
resistance to blood flow, fetal hypertension, and increased pulsatility stresses shown to lead …

Hyperelastic remodeling in the intrauterine growth restricted (IUGR) carotid artery in the near-term fetus

RB Dodson, PJ Rozance, E Reina-Romo… - Journal of …, 2013 - Elsevier
A constitutive model for a fiber reinforced hyperelastic material was applied to understand
arterial fiber remodeling in a sheep model of Intrauterine Growth Restriction (IUGR). IUGR is …

[HTML][HTML] Differences in placental capillary shear stress in fetal growth restriction may affect endothelial cell function and vascular network formation

WM Tun, CH Yap, SN Saw, JL James, AR Clark - Scientific Reports, 2019 - nature.com
Fetal growth restriction (FGR) affects 5–10% of pregnancies, leading to clinically significant
fetal morbidity and mortality. FGR placentae frequently exhibit poor vascular branching, but …

Investigating the upstream and downstream hemodynamic boundary conditions of healthy and growth-restricted rat feto-placental arterial networks

N Bappoo, LJ Kelsey, Y Tongpob, C Wyrwoll… - Annals of Biomedical …, 2021 - Springer
The placenta uniquely develops to orchestrate maternal adaptations and support fetal
growth and development. The expansion of the feto-placental vascular network, in part …

[HTML][HTML] Placental underperfusion in a rat model of intrauterine growth restriction induced by a reduced plasma volume expansion

K Bibeau, B Sicotte, M Béland, M Bhat, L Gaboury… - PLoS …, 2016 - journals.plos.org
Lower maternal plasma volume expansion was found in idiopathic intrauterine growth
restriction (IUGR) but the link remains to be elucidated. An animal model of IUGR was …

[HTML][HTML] Dynamic modeling of uteroplacental blood flow in IUGR indicates vortices and elevated pressure in the intervillous space–a pilot study

CJ Roth, E Haeussner, T Ruebelmann, F Koch… - Scientific Reports, 2017 - nature.com
Ischemic placental disease is a concept that links intrauterine growth retardation (IUGR) and
preeclampsia (PE) back to insufficient remodeling of uterine spiral arteries. The rheological …