[HTML][HTML] Early administration of tocilizumab in hospitalized COVID-19 patients with elevated inflammatory markers; COVIDSTORM—a prospective, randomized, single …
N Broman, T Feuth, T Vuorinen, M Valtonen… - Clinical Microbiology …, 2022 - Elsevier
Objectives Severe COVID-19 is associated with an imbalanced immune response. We
hypothesized that patients with enhanced inflammation, as demonstrated by increased …
hypothesized that patients with enhanced inflammation, as demonstrated by increased …
Impact of tocilizumab administration on mortality in severe COVID-19
A Tsai, O Diawara, RG Nahass, L Brunetti - Scientific reports, 2020 - nature.com
The novel coronavirus disease 2019 (COVID-19) worldwide pandemic has placed a
significant burden on hospitals and healthcare providers. The immune response to this …
significant burden on hospitals and healthcare providers. The immune response to this …
Effect of tocilizumab vs standard care on clinical worsening in patients hospitalized with COVID-19 pneumonia: a randomized clinical trial
C Salvarani, G Dolci, M Massari, DF Merlo… - JAMA internal …, 2021 - jamanetwork.com
Importance The coronavirus disease 2019 (COVID-19) pandemic is threatening billions of
people worldwide. Tocilizumab has shown promising results in retrospective studies in …
people worldwide. Tocilizumab has shown promising results in retrospective studies in …
Promising effects of tocilizumab in COVID-19: a non-controlled, prospective clinical trial
Background The clinical presentation of SARS-CoV-2 infection ranges from mild symptoms
to severe complications, including acute respiratory distress syndrome. In this syndrome …
to severe complications, including acute respiratory distress syndrome. In this syndrome …
Association between early treatment with tocilizumab and mortality among critically ill patients with COVID-19
Importance Therapies that improve survival in critically ill patients with coronavirus disease
2019 (COVID-19) are needed. Tocilizumab, a monoclonal antibody against the interleukin 6 …
2019 (COVID-19) are needed. Tocilizumab, a monoclonal antibody against the interleukin 6 …
Tocilizumab for patients with COVID-19 pneumonia. The single-arm TOCIVID-19 prospective trial
Background Tocilizumab blocks pro-inflammatory activity of interleukin-6 (IL-6), involved in
pathogenesis of pneumonia the most frequent cause of death in COVID-19 patients …
pathogenesis of pneumonia the most frequent cause of death in COVID-19 patients …
Outcomes in patients with severe COVID-19 disease treated with tocilizumab: a case–controlled study
Background COVID-19 is an ongoing threat to society. Patients who develop the most
severe forms of the disease have high mortality. The interleukin-6 inhibitor tocilizumab has …
severe forms of the disease have high mortality. The interleukin-6 inhibitor tocilizumab has …
Mortality rates among hospitalized patients with COVID-19 infection treated with tocilizumab and corticosteroids: a Bayesian reanalysis of a previous meta-analysis
Importance A World Health Organization (WHO) meta-analysis found that tocilizumab was
associated with reduced mortality in hospitalized patients with COVID-19. However …
associated with reduced mortality in hospitalized patients with COVID-19. However …
Beneficial and harmful outcomes of tocilizumab in severe COVID‐19: a systematic review and meta‐analysis
M Rubio‐Rivas, CG Forero… - … : The Journal of …, 2021 - Wiley Online Library
Introduction The results of studies of tocilizumab (TCZ) in COVID‐19 are contradictory. Our
study aims to update medical evidence from controlled observational studies and …
study aims to update medical evidence from controlled observational studies and …
Tocilizumab therapy reduced intensive care unit admissions and/or mortality in COVID-19 patients
T Klopfenstein, S Zayet, A Lohse, JC Balblanc… - Medecine et maladies …, 2020 - Elsevier
Introduction No therapy has yet proven effective in COVID-19. Tocilizumab (TCZ) in patients
with severe COVID-19 could be an effective treatment. Method We conducted a …
with severe COVID-19 could be an effective treatment. Method We conducted a …