Aminoglycoside antibiotics have long been used in antibacterial therapy. Despite their
beneficial effects, aminoglycosides have considerable nephrotoxic and ototoxic side effects …

The toxicity of aminoglycosides including gentamicin (GEN), the most widely used drug in
this category, is believed to be related to the generation of reactive oxygen species (ROS) in …

The present study was designed to explore the possible protective effects of agmatine, a
known nitric oxide (NO) synthase inhibitor, against gentamicin-induced nephrotoxicity in …

The nephrotoxicity of amikacin (AK) was prevented with pentoxifylline (PTX) in a rat model.
Rats were received a single injection of AK (1.2 g/kg, ip) with or without PTX pretreatment …

Amikacin is a commonly used antibacterial drug that can cause significant nephrotoxic
effects in both humans and experimental animals. It has been reported that one mechanism …

Gentamicin (GM) is a widely used antibiotic against serious and life‐threatening infections,
but its usefulness is limited by the development of nephrotoxicity. The present study was …

Background: In recent publications, several mechanisms have been implicated in
gentamicin (GM) nephrotoxicity. Reactive oxygen species have been proposed as one of the …

Gentamicin (GM) is used against serious and life‐threatening infections, but its use is limited
by the occurrence of nephrotoxicity, which involves the generation of free radicals. In this …

Amikacin (AK) is an antibacterial drug, but it has remarkable nephrotoxic and ototoxic side
effects due to increase in reactive oxygen radicals. This study was established to determine …

Abstract BACKGROUND AND OBJECTIVE: Gentamicin is one of the aminoglycoside
antibiotics that commonly causes nephrotoxicity. Antioxidants are effective in reducing …