1, 2, 4-Triazole derivatives as novel and potent antifungal agents: Design, synthesis and biological evaluation
Fungal infections are still threatening human health due to resistance to existing drugs,
therefore, the design and development of novel antifungal agents is to be necessary and …
therefore, the design and development of novel antifungal agents is to be necessary and …
New indazole–1, 2, 3–triazoles as potent antimicrobial agents: Design, synthesis, molecular modeling and in silico ADME profiles
SK Gandham, AA Kudale, TR Allaka, K Chepuri… - Journal of Molecular …, 2024 - Elsevier
Our current work is aimed at synthesizing novel derivatives of 1, 2, 3–triazolyl–indazoles,
applying docking techniques and biological evaluation in order to find active promising …
applying docking techniques and biological evaluation in order to find active promising …
Design, synthesis and mechanistic study of new 1, 2, 4-triazole derivatives as antimicrobial agents
NH Amin, MT El-Saadi, AA Ibrahim… - Bioorganic …, 2021 - Elsevier
Abstract Novel 5-amino-1, 2, 4-triazole derivatives and their cyclized 1, 2, 4-triazolo [1, 5-a]
pyrimidine analogues were designed, synthesized and evaluated for their antimicrobial …
pyrimidine analogues were designed, synthesized and evaluated for their antimicrobial …
Imidazole derivatives as novel and potent antifungal agents: Synthesis, biological evaluation, molecular docking study, molecular dynamic simulation and ADME …
S Sadeghian, F Bekhradi, F Mansouri, R Razmi… - Journal of Molecular …, 2024 - Elsevier
Fungal infections have become a serious threat to human health due to their high incidence
and mortality. In this study, a new set of imidazole derivatives (7a-f) were synthesized and …
and mortality. In this study, a new set of imidazole derivatives (7a-f) were synthesized and …
Novel 1, 2, 4‐Triazoles as Antifungal Agents
Z Kazeminejad, M Marzi, A Shiroudi… - BioMed Research …, 2022 - Wiley Online Library
The development of innovative antifungal agents is essential. Some fungicidal agents are no
longer effective due to resistance development, various side effects, and high toxicity …
longer effective due to resistance development, various side effects, and high toxicity …
[PDF][PDF] ADME/T prediction, molecular docking, and biological screening of 1, 2, 4-triazoles as potential antifungal agents
Clinical needs for new antifungal agents have gradually and steadily increased with the rise
of AIDS-related mycoses, and the change in spectrum of fatal disseminated fungal …
of AIDS-related mycoses, and the change in spectrum of fatal disseminated fungal …
Exploring 1, 2, 3-triazole derivatives by using in vitro and in silico assays to target new antifungal agents and treat Candidiasis
TF Santos, JB de Jesus, PM Neufeld, AK Jordão… - Medicinal Chemistry …, 2017 - Springer
Candidiasis is a serious public health problem that currently affects not only
immunodeficient patients with predisposing conditions, but also immunocompetent …
immunodeficient patients with predisposing conditions, but also immunocompetent …
Synthesis, characterization, and molecular docking study of some novel imidazole derivatives as potential antifungal agents
The azole pharmacophore is still regarded as a viable lead structure for the synthesis of
more effective antifungal agents. In this study, two novel series of imidazole derivatives …
more effective antifungal agents. In this study, two novel series of imidazole derivatives …
Molecular docking, design, synthesis and antifungal activity study of novel triazole derivatives
J Wu, T Ni, X Chai, T Wang, H Wang, J Chen… - European journal of …, 2018 - Elsevier
The incidence of life-threatening fungal infections has dramatically increased for decades. In
order to develop novel antifungal agents, two series of (2 R, 3R)-1-(1H-1, 2, 4-triazol-1-yl)-2 …
order to develop novel antifungal agents, two series of (2 R, 3R)-1-(1H-1, 2, 4-triazol-1-yl)-2 …
5-Fluoro-1H-indole-2, 3-dione-triazoles-synthesis, biological activity, molecular docking, and DFT study
An environmental friendly heterogeneous catalyst Cell-CuI-NPs was employed for the
synthesis of biologically promising 1-((1-aryl)-1H-1, 2, 3-triazol-4-yl) methyl-5-fluoroindoline …
synthesis of biologically promising 1-((1-aryl)-1H-1, 2, 3-triazol-4-yl) methyl-5-fluoroindoline …