A combination of indole-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and …

Y Nakamura, S Yogosawa, Y Izutani, H Watanabe… - Molecular cancer, 2009 - Springer
Background The chemopreventive effects of dietary phytochemicals on malignant tumors
have been studied extensively because of a relative lack of toxicity. To achieve desirable …

Anti-cancer effects of naturally occurring compounds through modulation of signal transduction and miRNA expression in human colon cancer cells

M Kumazaki, S Noguchi, Y Yasui, J Iwasaki… - The Journal of nutritional …, 2013 - Elsevier
Much evidence indicates that various naturally occurring compounds have an anti-cancer
effect, but the detailed mechanisms are not well understood. In this study, we selected anti …

Genistein induces activation of the mitochondrial apoptosis pathway by inhibiting phosphorylation of Akt in colorectal cancer cells

J Qin, JA Teng, Z Zhu, JX Chen… - Pharmaceutical biology, 2016 - Taylor & Francis
Context: Genistein inhibits the proliferation and induces apoptosis of colorectal cancer cells;
however, the underling molecular mechanisms remain to be determined. Aim: The aim of …

Apoptosis and autophagy induction as mechanism of cancer prevention by naturally occurring dietary agents

E Mukhtar, V Mustafa Adhami, N Khan… - Current drug …, 2012 - ingentaconnect.com
Nontoxic naturally occurring compounds, especially those from dietary sources, are
receiving increasing consideration for prevention and treatment of diseases including …

[HTML][HTML] Inhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells

J Yang, C Pi, G Wang - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Apigenin is a dietary flavonoid with known antioxidant and antitumor effects against several
types of cancers by promoting cell death and inducing cell cycle arrest. Apigenin also …

Natural compounds modulate the crosstalk between apoptosis-and autophagy-regulated signaling pathways: Controlling the uncontrolled expansion of tumor cells

C Braicu, O Zanoaga, AA Zimta, AB Tigu… - Seminars in Cancer …, 2022 - Elsevier
Due to the high number of annual cancer–related deaths, and the economic burden that this
malignancy affects today's society, the study of compounds isolated from natural sources …

Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells

EP Moiseeva, GM Almeida, GDD Jones… - Molecular cancer …, 2007 - AACR
Dietary phytochemicals exhibit chemopreventive potential in vivo through persistent low-
dose exposures, whereas mechanistic in vitro studies with these agents generally use a …

Terpenoids' anti-cancer effects: Focus on autophagy

C El-Baba, A Baassiri, G Kiriako, B Dia, S Fadlallah… - Apoptosis, 2021 - Springer
Terpenoids are the largest class of natural products, most of which are derived from plants.
Amongst their numerous biological properties, their anti-tumor effects are of interest for they …

Senolytic flavonoids enhance type-I and type-II cell death in human radioresistant colon cancer cells through AMPK/MAPK pathway

M Russo, S Moccia, D Luongo, GL Russo - Cancers, 2023 - mdpi.com
Simple Summary The role of autophagy and senescence in cancer resistance to ionizing
radiation as a response to genotoxic stress is still only partially explored. The flavonoids …

Ginkgolic acid induces interplay between apoptosis and autophagy regulated by ROS generation in colon cancer

Y Liu, B Yang, L Zhang, X Cong, Z Liu, Y Hu… - Biochemical and …, 2018 - Elsevier
Presently, developing effective anti-colon cancer drugs still remains to be important.
Ginkgolic acids (GA), as a botanical drug extracted from the seed coat of Ginkgo biloba L …