Simple Summary Metastasis, the process by which cancer cells escape primary tumor site
and colonize distant organs, is responsible for most cancer-related deaths. The tumor …

The concept that progression of cancer is regulated by interactions of cancer cells with their
microenvironment was postulated by Stephen Paget over a century ago. Contemporary …

Tumor microenvironment, including extracellular matrix (ECM) and stromal cells, is a key
player during tumor development, from initiation, growth and progression to metastasis …

Evidence is accumulating that the malignant phenotype of a given tumor is dependent not
only on the intrinsic characteristics of tumor cells, but also on the cooperative interactions of …

Simple Summary Accurate in vitro modeling of diseases is essential to making breakthrough
and clinically relevant discoveries. Assays to examine the process of invasion—a classical …

Cancer development is highly associated to the physiological state of the tumor
microenvironment (TME). Despite the existing heterogeneity of tumors from the same or from …

Extracellular matrix interactions have essential roles in normal physiology and many
pathological processes. Although the importance of extracellular matrix interactions in …

The tumor microenvironment plays a critical role in tumorigenesis and metastasis. As tightly
controlled extracellular matrix homeostasis is lost during tumor progression, a dysregulated …

The extracellular matrix is perturbed in tumors. The tumor matrix promotes the growth,
survival, and invasion of the cancer and modifies fibroblast and immune cell behavior to …

The multistep process of metastasis is a major hallmark of cancer progression involving the
cointeraction and coevolution of the tumor and its microenvironment. In the tumor …