Alternative macrophage activation is associated with exacerbated disease in murine models
of pulmonary cryptococcosis. The present study evaluated the efficacy of interferon-γ …

We evaluated cell-mediated immune (CMI) responses in mice given a pulmonary infection
with a Cryptococcus neoformans strain engineered to produce the Th1-type cytokine gamma …

Experimental pulmonary Cryptococcus neoformans infection in BALB/c mice is associated
with polarized Th2-type cytokine production, alternative macrophage activation, and severe …

Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening
pneumonia and meningoencephalitis in immune compromised individuals. Previous studies …

Fungal pathogens are notorious for causing chronic and latent infections, but the
mechanism by which they evade the immune response is poorly understood. A major …

The pathogenesis of Cryptococcus neoformans pulmonary infection in the rat was studied
after intratracheal inoculation. Lungs were examined at various times following infection for …

Increasing evidence indicates that T cell-dependent, interferon gamma (IFN gamma)-
induced activation of murine macrophages and nitric oxide (NO) production plays an …

The major capsular polysaccharide of Cryptococcus neoformans, glucuronoxylomannan
(GXM), is recognized by Toll-like receptor 2 (TLR2), TLR4, and CD14. In these studies, mice …

We investigated the pathogenesis of pulmonary Cryptococcus neoformans infection and
passive Ab efficacy in mice deficient in inducible NO synthase (NOS2−/−) and the parental …

Cryptococcus neoformans (Cn) is a fungal pathogen that is a serious health threat to
immunocompromised individuals. Upon environmental exposure, infectious fungal …