The efficacy of monoclonal antibody (MAb 2H1) against diverse strains of Cryptococcus
neoformans was studied in a murine model of intravenous infection. For six of eight strains …

We investigated the role of TNF-α in the host defence mechanism against infection with a
virulent strain of Cryptococcus neoformans. Administration of exogenous recombinant …

Macrophage cytotoxicity for Cryptococcus neoformans was investigated by culturing human
alveolar macrophage (AM) with a thln-capsuled clone of C. neoformans In a polypropylene …

Upon ingestion by macrophages, Cryptococcus neoformans can survive and replicate
intracellularly unless the macrophages become classically activated. The mechanism …

Cell-mediated immunity is critical to host defenses against the fungal infection
cryptococcosis. Here, two functions critical to effective cell-mediated immunity (CMI) …

Cryptococcus neoformans var. gattii (serotype B and C) isolates have a relative predilection
for immunocompetent hosts, and C. neoformans var. neoformans (serotype A and D) …

Moderately virulent strains of Cryptococcusneoformans, inoculated via the trachea, cause a
pulmonary infection in BALB/c mice that was gradually resolved by T lymphocyte-dependent …

Previous investigations have demonstrated that macrophages play a critical role in the first‐
line cellular defense mechanism against infection with Cryptococcus neoformans. In the …

Human infection with Cryptococcus neoformans, a common fungal pathogen, follows
deposition of yeast spores in the lung alveoli. The subsequent host–pathogen interaction …

Background Cryptococcus neoformans is an encapsulated yeast that is a facultative
intracellular pathogen. The interaction between macrophages and C. neoformans is critical …