Cryptococcus neoformans is a major fungal pathogen and is a relatively common cause of
life-threatening meningoencephalitis. Glyphosate is a widely used herbicide that inhibits the …

Melanin is a major virulence factor in pathogenic fungi that enhances the ability of fungal
cells to resist immune clearance. Cryptococcus neoformans is an important human …

Cryptococcus neoformans is an opportunistic fungal pathogen which becomes heavily
melanized in the presence of phenolic substrates such as L-dopa. Various drugs are known …

Cryptococcus spp. are human pathogens that cause 181,000 deaths per year. In this work,
we systematically investigated the virulence attributes of Cryptococcus spp. clinical isolates …

Cryptococcus neoformans is unusual among melanotic fungi in that it requires an
exogenous supply of precursor to synthesize melanin. C. neoformans melanizes during …

Cryptococcus neoformans is an opportunistic fungal pathogen and the causative agent of
the disease cryptococcosis. Cryptococcosis is initiated as a pulmonary infection and in …

Although the pathogenesis of cerebral cryptococcosis is poorly understood, local immune
cells, such as microglia and astrocytes, likely play a critical role in containing infection …

On the basis of the clinical observation that the cerebrospinal fluid (CSF) of patients with
cryptococcal meningitis contains high levels of the chemokine interleukin (IL)-8 but few …

Melanin has been proposed as a virulence factor in Cryptococcus neoformans, but its
presence has not been shown unambiguously in vivo. Validated methods used previously to …

Cryptococcus neoformans is a pathogenic fungus that causes meningitis worldwide,
particularly in human immunodeficiency virus (HIV)–infected individuals. Although …