Emergence of drug‐resistant cytomegalovirus in the era of valganciclovir prophylaxis: therapeutic implications and outcomes

AJ Eid, SK Arthurs, PJ Deziel, MP Wilhelm… - Clinical …, 2008 - Wiley Online Library
Background: Valganciclovir prophylaxis is reportedly associated with a low incidence of
ganciclovir‐resistant cytomegalovirus (CMV). We assessed the incidence, clinical features …

Absence of cytomegalovirus-resistance mutations after valganciclovir prophylaxis, in a prospective multicenter study of solid-organ transplant recipients

G Boivin, N Goyette, C Gilbert, N Roberts… - The Journal of …, 2004 - academic.oup.com
We investigated the emergence of cytomegalovirus (CMV) ganciclovir-resistance mutations
in 301 high-risk solid-organ transplant (SOT) recipients after oral prophylaxis, for 100 days …

Perspectives in the treatment and prophylaxis of cytomegalovirus disease in solid-organ transplant recipients

G Torres-Madriz, HW Boucher - Clinical infectious diseases, 2008 - JSTOR
Cytomegalovirus (CMV) infection is an important complication of solid-organ transplantation.
The availability of potent antiviral therapies has decreased the incidence of CMV disease …

[HTML][HTML] New developments in the management of cytomegalovirus infection after solid organ transplantation

AJ Eid, RR Razonable - Drugs, 2010 - Springer
Despite remarkable advances in the diagnostic and therapeutic modalities for its
management, cytomegalovirus (CMV) remains one of the most important pathogens …

Use of high-dose ganciclovir for the treatment of cytomegalovirus replication in solid organ transplant patients with ganciclovir resistance-inducing mutations

I Gracia-Ahufinger, J Gutiérrez-Aroca, E Cordero… - …, 2013 - journals.lww.com
Background Experience with high-dose ganciclovir for the management of resistant
cytomegalovirus (CMV) replication in transplant patients is limited despite its adoption as an …

Cytomegalovirus resistance in solid organ transplant recipients treated with intravenous ganciclovir or oral valganciclovir

G Boivin, N Goyette, H Rollag, AG Jardine… - Antiviral …, 2009 - journals.sagepub.com
Background The rate of cytomegalovirus (CMV) mutations conferring ganciclovir resistance
was assessed in a trial comparing intravenous ganciclovir and oral valganciclovir for …

[HTML][HTML] Efficacy and safety of valganciclovir vs. oral ganciclovir for prevention of cytomegalovirus disease in solid organ transplant recipients

C Paya, A Humar, ED Dominguez, K Washburn… - American Journal of …, 2004 - Elsevier
We compared the efficacy and safety of valganciclovir with those of oral ganciclovir in
preventing cytomegalovirus (CMV) disease in high-risk seronegative solid organ transplant …

Clinical characteristics of 13 solid organ transplant recipients with ganciclovir‐resistant cytomegalovirus infection

CM Isada, B Yen‐Lieberman, NS Lurain… - Transplant infectious …, 2002 - Wiley Online Library
Background. Ganciclovir‐resistant (GCV‐R) cytomegalovirus (CMV) is now being reported
with increasing frequency in solid organ transplant recipients. Objective. To describe the …

Clinical impact of ganciclovir‐resistant cytomegalovirus infections in solid organ transplant patients

G Boivin, N Goyette, C Gilbert, A Humar… - Transplant infectious …, 2005 - Wiley Online Library
Clinical consequences of ganciclovir resistant cytomegalovirus (CMV) infections were
studied during 2 large prophylactic trials consisting of 100 days of valganciclovir or …

Ganciclovir‐resistant cytomegalovirus infection in solid organ transplant recipients: a single‐center retrospective cohort study

PG Young, J Rubin, M Angarone… - Transplant Infectious …, 2016 - Wiley Online Library
Background Ganciclovir‐resistant cytomegalovirus (GCV‐R CMV) is an emerging challenge
among solid organ transplant (SOT) recipients. The literature suggests that about 1% of …